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Newly-Published Colchicine Safety Data Provide First Evidence-Based Dosing Guidance to Avoid Potentially Serious Interactions With Commonly Prescribed Drugs
Posted 11 Aug 2011 by Drugs.com
- Paper Published in August Issue of Arthritis & Rheumatism Highlights Several Previously Unknown Drug-Drug Interactions - Colchicine Dose Reductions Necessary in Presence of Certain CYP3A4 or P-gp Inhibitors - Studies Supported URL Pharma Clinical Research Program that Led to FDA Approval of Colcrys® PHILADELPHIA, Aug. 11, 2011 /PRNewswire/ – Newly-published results from a series of colchicine safety studies provide physicians with the first evidence-based dosing guidance for colchicine when co-administered with certain commonly prescribed drugs, helping doctors and patients avoid serious and potentially life-threatening drug-drug interactions. The study results, published in a paper titled "Evidence Basis of a Novel Colchicine Dose Reduction Algorithm to Predict and Prevent Colchicine Toxicity in the Presence of P-gp/CYP450 3A4 Inhibitors," appear in the August issue of Arthritis ... Read more
Posted 1 Oct 2010 by Drugs.com
Drug commonly used to prevent gout, treat gout flares, and treat Familial Mediterranean Fever (FMF) ROCKVILLE, Md., Sept. 30, 2010--The U.S. Food and Drug Administration today took action against companies that manufacture, distribute, and/or market unapproved single-ingredient oral colchicine, a medication commonly used for the daily prevention of gout, to treat acute gout flare-ups, and for the treatment of Familial Mediterranean Fever (FMF). The companies are expected to stop manufacturing single-ingredient oral colchicine within 45 days and must stop shipping this unapproved product in interstate commerce within 90 days. A small amount of unapproved colchicine is expected to be available after these dates until supplies are exhausted. Many single ingredient oral colchicine products have been used by the medical community for decades. These and a variety of other medications have ... Read more