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Related terms: Clostridium difficile-Associated Diarrhea, CDAD, CDI, Clostridium difficile Infection

U.S. Death Toll From Infectious Diseases Unchanged: Study

Posted 14 days ago by Drugs.com

TUESDAY, Nov. 22, 2016 – The war against infectious diseases – medicine versus microbes – has been holding steady, with the U.S. death rate from these diseases about the same now as it was in 1980, new research says. But some of the specific disease threats have changed over the years, the study authors noted. Researchers found that the national death rate from infections stood at almost 46 deaths per 100,000 people in 2014. That compared with 42 per 100,000 in 1980. There were some major shifts during that time, however. The overall death rate went as high as 63 per 100,000 in 1995, owing to the HIV/AIDS epidemic, according to the study. AIDS deaths declined from then on, with the introduction of the "drug cocktails" that have turned HIV into a manageable chronic disease. But while there was progress against HIV, deaths from pneumonia and flu complications held steady over the ... Read more

Related support groups: Bacterial Infection, Influenza, Pneumonia, HIV Infection, Clostridial Infection, Viral Infection, West Nile Virus, Adjunct to Antibiotic Therapy, Prevention of Clostridium Difficile Infection Recurrence

FDA Approves Merck’s Zinplava (bezlotoxumab) to Reduce Recurrence of Clostridium difficile Infection

Posted 25 Oct 2016 by Drugs.com

KENILWORTH, N.J.--(BUSINESS WIRE) October 21, 2016 --Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved Zinplava (bezlotoxumab) Injection 25 mg/mL. Merck anticipates making Zinplava available in first quarter 2017. Zinplava is indicated to reduce recurrence of Clostridium difficile infection (CDI) in patients 18 years of age or older who are receiving antibacterial drug treatment of CDI and are at high risk for CDI recurrence. Zinplava is not indicated for the treatment of CDI. Zinplava is not an antibacterial drug. Zinplava should only be used in conjunction with antibacterial drug treatment of CDI. CDI is caused by bacteria that produce toxins, including toxin B. Symptoms of CDI include mild-to-severe diarrhea, abdominal pain and fever. The incidence of recurrent CDI is higher in certain ... Read more

Related support groups: Clostridial Infection, Zinplava, Bezlotoxumab

If Patient in the Hospital Bed Before You Got Antibiotics -- Take Heed

Posted 10 Oct 2016 by Drugs.com

MONDAY, Oct. 10, 2016 – When a hospital patient is taking antibiotics, the next person to use the same bed may face an elevated risk of infection with the dangerous germ Clostridium difficile, a new study suggests. C. difficile, a bacterium that causes inflammation of the colon and causes life-threatening diarrhea, is found in U.S. hospitals. Scientists have known that antibiotic use can contribute to the germ's spread, but this new report says it's not just the patient taking the medication who's at risk. Because the germ spores can persist, patients later assigned to the same hospital bed may have increased odds of getting C. difficile, researchers found. "This study provides evidence that there is a herd effect with antibiotics," said lead researcher Dr. Daniel Freedberg, a gastroenterologist at Columbia University Medical Center in New York City. "In other words, antibiotics have ... Read more

Related support groups: Clostridial Infection

Frozen as Good as Fresh for Fecal Transplant: Study

Posted 12 Jan 2016 by Drugs.com

TUESDAY, Jan. 12, 2016 – Researchers say they have verified the effectiveness of a quicker way to rid people of recurring C. difficile bacterial infection. A new clinical trial has shown that frozen stool samples work just as well as freshly donated samples when treating a tough C. difficile infection through a procedure called fecal transplantation. Doctors have used frozen stool samples to treat C. difficile for a couple of years, because the prepackaged samples allow for much easier and swifter treatment than identifying and screening a fresh donor, said lead author Dr. Christine Lee, director of the microbiology residency program at McMaster University in Ontario, Canada. "Donor screening can take one to two weeks," Lee said. "If a person requires fecal transplant right away, then that's not possible." The clinical trial showed that patients do not pay a price for the convenience ... Read more

Related support groups: Diarrhea, Gastrointestinal Disorders, Bowel Preparation, Diarrhea, Chronic, Clostridial Infection, Diarrhea, Acute, Diagnosis and Investigation, Fecal Incontinence

Post-Op Bacterial Infection Raises Odds for Complications, Death

Posted 25 Nov 2015 by Drugs.com

WEDNESDAY, Nov. 25, 2015 – People recuperating from surgery are much more likely to die or develop complications if they become infected with a dangerous diarrhea-causing bacteria, a new study suggests. Patients at VA hospitals who contracted Clostridium difficile following surgery were five times more likely to die and 12 times more likely to suffer a complication of the heart, lung, kidneys or nervous system, according to findings published online Nov. 25 in the journal JAMA Surgery. "C. difficile infection is a big hit to take for people who are already behind the eight-ball," said Dr. Brian Zuckerbraun, a surgeon at the VA Pittsburgh Healthcare System who co-wrote an accompanying editorial. "It's just a big insult to their system, when they are vulnerable." C. difficile is a tough and opportunistic bacteria that can invade the intestines of people whose gut bacteria have been wiped ... Read more

Related support groups: Infections, Surgery, Bacterial Infection, Bacterial Skin Infection, Clostridial Infection, Bacteremia

Review Finds Fecal Transplants Work Well But Need Tight Regulation

Posted 21 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 21, 2015 – The growing use of fecal transplants needs to be carefully controlled, experts say. The therapy is increasingly being used to treat people with life-threatening intestinal infections, such as those caused by the bacterium Clostridium difficile. The procedure involves transferring fecal matter from a healthy donor into the intestine of a patient so that healthy bacteria can re-colonize the bowel. Researchers analyzed available evidence and found that fecal transplants were 85 percent successful in treating patients, compared with 20 percent for standard antibiotic treatment. A recent clinical trial was halted early because fecal transplantation proved so effective, with a 90 percent success rate compared to 26 percent for powerful antibiotics, the researchers noted. After more than 7,000 fecal transplants, few harmful effects have been reported and the ... Read more

Related support groups: Diabetes, Type 2, Obesity, Irritable Bowel Syndrome, Colitis, Clostridial Infection, Pseudomembranous Colitis

Non-Antibiotic Medicine May Fight Drug-Resistant 'Superbug'

Posted 23 Sep 2015 by Drugs.com

WEDNESDAY, Sept. 23, 2015 – A new mouse study suggests that a drug with a known safety record in humans might be a new weapon in the fight against the potentially deadly intestinal infection known as C. difficile. The drug is called ebselen, and it was well-tolerated in humans when tested as a possible treatment in a variety of clinical trials, including for stroke and bipolar disorder. Although ebselen has never been approved as a treatment for any condition in humans, the current research team thought the drug might help prevent the spread of infection in people with C. difficile. When the researchers gave ebselen to infected mice, the drug appeared to knock out the toxic activity of C. difficile without inflicting the collateral damage on good bacteria that's normally associated with antibiotic treatment, the study reported. The results were "very encouraging," said study senior ... Read more

Related support groups: Clostridial Infection

Better Control of Drug-Resistant Germs Could Save Thousands of Lives: CDC

Posted 4 Aug 2015 by Drugs.com

TUESDAY, Aug. 4, 2015 – An immediate, focused effort to halt the spread of antibiotic-resistant germs could save tens of thousands of lives and prevent hundreds of thousands of new infections over the next five years, a new government report suggests. As many as 37,000 lives could be saved, and 619,000 new infections prevented, if community health departments and health care facilities form tight support networks to quickly identify and address emerging outbreaks of antibiotic-resistant bacteria, said report author Dr. John Jernigan. He directs the Office of HAI (Health care-Associated Infections) Prevention Research and Evaluation at the U.S. Centers for Disease Control and Prevention. "When health care facilities and health departments in a community work together to share information about resistance, and then use that information to guide and target prevention efforts, then we ... Read more

Related support groups: Infections, Amoxicillin, Metronidazole, Doxycycline, Bacterial Infection, Clindamycin, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Augmentin, Levaquin, Flagyl, Zithromax, Trimethoprim, Sulfamethoxazole, Nitrofurantoin, Erythromycin, Minocycline, Clarithromycin

Recent Hospitalization Might Raise Blood Infection Risk, Study Says

Posted 3 Jun 2015 by Drugs.com

WEDNESDAY, June 3, 2015 – A routine hospital stay may put older adults at risk for a potentially deadly condition called sepsis, according to a new study. Sepsis is a catastrophic, whole-body response to infection, according to the researchers. The study looked at data from nearly 11,000 older Americans. Over 12 years, there were 43,000 hospitalizations. The researchers found people were three times more likely to develop sepsis within three months after leaving the hospital than at any other time. The analysis also showed that the risk of sepsis three months after a hospital stay was 30 percent higher for those who received care for any type of infection. The risk of sepsis three months after hospitalization was 70 percent higher for those who had an intestinal infection caused by Clostridium difficile (or C. difficile) bacteria, the study revealed. One in 10 C. difficile infection ... Read more

Related support groups: Sepsis, Clostridial Infection, Wound Sepsis

Outbreaks of Gut 'Superbug' More Common in Northeast: Study

Posted 5 May 2015 by Drugs.com

TUESDAY, May 5, 2015 – Infections with the superbug known as Clostridium difficile have been the most prevalent in the Northeast during the past decade, new U.S. research shows. University of Texas researchers looked at slightly more than 2 million cases of infection with the germ, which causes colon inflammation and life-threatening diarrhea. The bug causes more health care-related infections in U.S. hospitals than any other, according to the U.S. Centers for Disease Control and Prevention. The findings were published in the May issue of the American Journal of Infection Control. C. difficile costs as much as $4.8 billion in estimated extra health care costs per year, according to CDC estimates. Roughly half a million infections occurred in 2011, killing 29,000 patients within a month of their diagnosis, according to the agency. The University of Texas researchers found the Northeast ... Read more

Related support groups: Infections, Clostridial Infection

'Good' Bacteria Might Fight Common Hospital Infection: Study

Posted 5 May 2015 by Drugs.com

TUESDAY, May 5, 2015 – Researchers may have found a new way to combat a stubborn and potentially deadly gut infection: a friendly version of the culprit bacteria itself. The infection, caused by the bug Clostridium difficile, is a common scourge in hospitals. And experts say the findings, published May 5 in the Journal of the American Medical Association, are important. Toxic strains of C. difficile bacteria cause diarrhea, abdominal cramps and, in some cases, severe inflammation of the colon. The infection commonly strikes people during or after a hospital stay – usually those who've had a long course of antibiotics or have a weakened immune system. C. difficile infections are at an all-time high in U.S. hospitals, said lead researcher Dr. Dale Gerding, a professor of medicine at Loyola University Chicago Stritch School of Medicine. A recent U.S. government report said almost half a ... Read more

Related support groups: Acidophilus, Clostridial Infection, Florastor, Lactobacillus Acidophilus, VSL#3, Flora-Q, Floranex, Saccharomyces Boulardii Lyo, Bio-K+, Florajen, Restora, Probiotic Formula, Florajen3, Flora-Q 2, Bacid, Culturelle DS, Novaflor, Bifidobacterium Infantis, Superdophilus, Lactobacillus Reuteri

Fecal Transplant Helps Fight Off Dangerous Gut Infection: Review

Posted 4 May 2015 by Drugs.com

MONDAY, May 4, 2015 – Though saddled with an undeniable "yuck factor," fecal transplantation appears to be a safe and effective way to combat a serious intestinal infection, according to a new review. Fecal transplantation, also known as fecal bacteriotherapy, is a procedure that involves the removal of stool from a healthy donor and infusion of that stool – and all the healthy bacteria it contains – into the microbial environment of the sick patient. Specifically, the review found that for recurrent infections caused by the bacteria Clostridium difficile (C. difficile), the intervention is successful 85 percent of the time. Fecal transplants also helped 55 percent of patients for whom standard drug treatments didn't work. C. difficile can be picked up in hospitals and doctors' offices, and in 2011 the bacteria was to blame for 500,000 infections and 29,000 deaths, according to the ... Read more

Related support groups: Diarrhea, Colitis, Gastrointestinal Disorders, Bowel Preparation, Diarrhea, Chronic, Clostridial Infection, Erosive Gastritis

Half of U.S. Hospitals Could Do More to Prevent Serious Infections, Study Finds

Posted 29 Apr 2015 by Drugs.com

WEDNESDAY, April 29, 2015 – Too few hospitals in the United States are doing everything they can to protect patients from a potentially deadly intestinal infection, a new study finds. Researchers from the University of Michigan surveyed almost 400 hospitals nationwide to determine what measures they had taken to prevent Clostridium difficile infections, which kill nearly 30,000 Americans a year and cause illness in hundreds of thousands more. Hospital patients are at high risk for C. difficile infections and for suffering serious effects, especially if they have taken antibiotics, which disrupt the normal community of bacteria in their digestive systems. Symptoms include diarrhea, fever, nausea and loss of appetite. "C. difficile infection over the last decade has emerged as a threat to patients, especially the most vulnerable and the elderly, and has increased in incidence and ... Read more

Related support groups: Infections, Metronidazole, Bactrim, Flagyl, Bactrim DS, Sulfamethoxazole/Trimethoprim, Xifaxan, Polymyxin B, Septra, Zyvox, Bacitracin, Rifaximin, Metro, SMZ-TMP DS, Clostridial Infection, Septra DS, Sulfatrim, Chloramphenicol, Cotrimoxazole, Flagyl IV

Fecal Transplant Treats Serious, Recurrent Intestinal Infection

Posted 30 Mar 2015 by Drugs.com

MONDAY, March 30, 2015 – Fecal transplants, using stool from a donor, have been successful at treating a serious gut infection, researchers report. The infection is called Clostridium difficile. It causes diarrhea and severe abdominal pain and kills thousands of people worldwide each year, the authors of the small study explained. It's believed that the infection overwhelms the good bacteria required to maintain a healthy intestine. The fecal transplant method was developed to treat people with C. difficile infections, particularly those who have repeat infections. Fecal matter is collected from a donor, purified, mixed with a saline solution and transferred to the patient, usually by colonoscopy. However, not much is known about the long-term stability of fecal transplants, the University of Minnesota researchers pointed out. The study, published in the current issue of the journal ... Read more

Related support groups: Clostridial Infection

Dangerous C. Difficile Germ Infects 500,000 Americans a Year: CDC

Posted 26 Feb 2015 by Drugs.com

WEDNESDAY, Feb. 25, 2015 – Almost half a million Americans were infected with the bacteria Clostridium difficile in 2011, and 29,000 died within a month of diagnosis, U.S. health officials report. "Infections with C. difficile have become increasingly common over the last few decades, and are seen in patients in health-care facilities as well as people in their communities," Dr. Michael Bell said at a U.S. Centers for Disease Control and Prevention press conference Wednesday. C. difficile, which causes inflammation of the colon and deadly diarrhea, is often linked to antibiotic use, said Bell, deputy director of healthcare quality promotion at the CDC's National Center for Emerging and Zoonotic Infectious Diseases. Antibiotics can destroy the natural bacterial balance in the colon, allowing C. difficile to take over, he explained. These infections can be prevented by controlling use of ... Read more

Related support groups: Metronidazole, Bactrim, Flagyl, Bactrim DS, Sulfamethoxazole/Trimethoprim, Xifaxan, Polymyxin B, Septra, Zyvox, Bacitracin, Rifaximin, Metro, SMZ-TMP DS, Clostridial Infection, Septra DS, Chloramphenicol, Sulfatrim, Cotrimoxazole, Flagyl IV, Flagyl IV RTU

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