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Cilastatin / Imipenem News

'Superbug' Gene Spotted on U.S. Pig Farm

Posted 3 days ago by Drugs.com

MONDAY, Dec. 5, 2016 – Scientists have identified a troubling new type of antibiotic resistance among U.S. farm animals. The drugs at issue are the carbapenem class of antibiotics. In hospitals, such drugs are considered a last line of defense against hard-to-treat bacterial infections. In the United States, carbapenem antibiotics have been banned for veterinary use, to minimize the risk that antibiotic resistance might develop among animals and spread to humans. And though it has already been identified among European and Asian livestock, there had been no indication of a resistance problem on American farms until now. But, following a five-month screening of a single American pig farm in 2015, researchers concluded that carbapenem resistance has in fact gained a foothold in U.S. livestock. "For now, we think that this is a rare and unusual occurrence," said study author Thomas ... Read more

Related support groups: Infections, Bacterial Infection, Methicillin-Resistant Staphylococcus Aureus Infection, Ertapenem, Meropenem, Invanz, Merrem, Cilastatin/Imipenem, Primaxin IM, Merrem Novaplus, Primaxin IV, Doribax, Doripenem

Kids Can Beat 'Complex' Pneumonia Without IV Antibiotics: Study

Posted 17 Nov 2016 by Drugs.com

THURSDAY, Nov. 17, 2016 – Antibiotics taken orally are as effective – and doubtless much more welcome – than intravenous antibiotics for children recovering at home from complex pneumonia, a new study finds. Youngsters with complex pneumonia typically have to take antibiotics for one to three weeks after they leave the hospital, the researchers noted. To see if one medication method outperformed the other, the investigators looked at more than 2,100 children treated for complex pneumonia at 36 U.S. hospitals. Not only were oral antibiotics as effective as IV ones, they also avoided the risk of infection and other complications related to so-called peripherally inserted central venous catheters ("PICC lines"), which are used to administer intravenous antibiotics, the researchers said. "PICC line complications can be serious, resulting in hospital readmission, additional procedures and ... Read more

Related support groups: Infections, Amoxicillin, Doxycycline, Bacterial Infection, Cephalexin, Azithromycin, Bactrim, Pneumonia, Augmentin, Keflex, Zithromax, Sulfamethoxazole, Erythromycin, Clarithromycin, Minocycline, Bactrim DS, Clavulanate, Cefdinir, Tetracycline, Amoxicillin/Clavulanate

CDC: Too Many Antibiotics Still Being Prescribed in U.S.

Posted 19 Sep 2016 by Drugs.com

MONDAY, Sept. 19, 2016 – Despite growing concerns about creating drug-resistant bacteria, overprescribing of antibiotics in U.S. hospitals didn't drop between 2006 and 2012, according to a new federal report. Over that time period, 55 percent of patients received at least one dose of antibiotics during their hospital stay, whether it was needed or not, researchers from the U.S. Centers for Disease Control and Prevention said. "Antibiotic use remains common, and use of the most powerful antibiotics is rising," said lead researcher James Baggs, a CDC epidemiologist. Although the use of antibiotics remained about the same during the study period, a significant increase was seen in the use of newer antibiotics, Baggs said. "Because inappropriate antibiotic use increases the risk of antibiotic resistance and other side effects, continued monitoring of antibiotic use is critical to future ... Read more

Related support groups: Infections, Amoxicillin, Doxycycline, Bacterial Infection, Bactrim, Cipro, Ciprofloxacin, Levaquin, Augmentin, Trimethoprim, Sulfamethoxazole, Nitrofurantoin, Minocycline, Methicillin-Resistant Staphylococcus Aureus Infection, Bacterial Skin Infection, Levofloxacin, Macrobid, Clavulanate, Bactrim DS, Tetracycline

FDA clears first test to detect specific genetic markers for certain antibiotic-resistant bacteria directly from clinical specimens

Posted 29 Jun 2016 by Drugs.com

June 29, 2016 – The U.S. Food and Drug Administration today cleared for marketing the Xpert Carba-R Assay, an infection control aid that tests patient specimens to detect specific genetic markers associated with bacteria that are resistant to Carbapenem antibiotics. Carbapenem antibiotics are widely used in hospitals to treat severe infections. These resistant organisms are commonly referred to as Carbapenem-resistant Enterobacteriaceae, or CRE, and have been reported in almost all states within the U.S. “By using a specimen taken directly from a patient to test for the presence of genetic markers, hospitals can more quickly identify these dangerous bacteria resistant to certain antibiotics,” said Alberto Gutierrez, M.D., director of the FDA’s Office of In Vitro Diagnostics and Radiological Health within the Center for Devices and Radiological Health. Current methods to identify colon ... Read more

Related support groups: Bacterial Infection, Ertapenem, Diagnosis and Investigation, Meropenem, Invanz, Merrem, Cilastatin/Imipenem, Primaxin IM, Merrem Novaplus, Primaxin IV, Doribax, Doripenem

U.S. Officials Confirm Superbug Resistant to All Antibiotics

Posted 27 May 2016 by Drugs.com

FRIDAY, May 27, 2016 – U.S. researchers have identified the nation's first patient with an infection resistant to all existing antibiotics. Scientists have warned for years the day could come when "superbugs" resisted all last-resort antibiotics. This new case, involving a 49-year-old Pennsylvania woman, suggests that day may soon be here. "It is the end of the road for antibiotics unless we act urgently," Dr. Tom Frieden, director of the U.S. Centers for Disease Control and Prevention, said at a National Press Club event in Washington, D.C., on Thursday. Although the patient survived, it's feared the resistance could spread to other bacteria, according to media reports. The woman was treated last month for a urinary tract infection at a military clinic in Pennsylvania. The culprit was identified as E. coli bacteria. It's a common type of germ. But in this case, tests showed it was ... Read more

Related support groups: Urinary Tract Infection, Bladder Infection, Trimethoprim, Nitrofurantoin, Macrobid, Prevention of Bladder infection, Macrodantin, Methenamine, Hiprex, Cystitis Prophylaxis, Fosfomycin, Ertapenem, Cystex, Meropenem, Invanz, Monurol, Methylene Blue, Urex, Mandelamine, Nalidixic Acid

Too Many People Still Take Unneeded Antibiotics: Study

Posted 3 May 2016 by Drugs.com

TUESDAY, May 3, 2016 – Nearly one-third of the antibiotics prescribed in the United States aren't appropriate for the conditions being treated, a new federal government study shows. "We were able to conclude that at least 30 percent of the antibiotics that are given in doctors' offices, emergency departments and hospital-based clinics are unnecessary, meaning that no antibiotics were needed at all," said lead researcher Dr. Katherine Fleming-Dutra. Such misuse has helped fuel the rise of antibiotic-resistant bacteria, which infect 2 million Americans and kill 23,000 every year, said Fleming-Dutra, a pediatrician and epidemiologist at the U.S. Centers for Disease Control and Prevention. Antibiotics are most misused in the treatment of short-term respiratory conditions, such as colds, bronchitis, sore throats, and sinus and ear infections, the researchers reported. "About half of ... Read more

Related support groups: Infections, Amoxicillin, Doxycycline, Bacterial Infection, Cephalexin, Sinusitis, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Levaquin, Augmentin, Tonsillitis/Pharyngitis, Keflex, Zithromax, Sulfamethoxazole, Cold Symptoms, Erythromycin, Clarithromycin, Minocycline

Drug Makers, Governments Sign Deal to Fight Drug-Resistant Infections

Posted 21 Jan 2016 by Drugs.com

A groundbreaking agreement between the drug industry and governments to work together to fight drug-resistant "superbugs" is expected to be announced Thursday. Under the deal, 74 drug makers, 11 diagnostic test makers, and nine industry groups pledge to work with each other and 16 countries to prevent and improve treatment of drug-resistant infections, the Associated Press reported. These infections are a serious threat to millions of people worldwide and a number of factors contribute to the problem, including overuse of antibiotics, declining drug industry research, and few new medicines to combat bacteria, viruses, parasites and fungi. The new deal – scheduled to be announced at the World Economic Forum in Davos, Switzerland – is the first to outline how the drug industry and governments should team up to prevent more drugs from becoming ineffective, to spur development of new ... Read more

Related support groups: Doxycycline, Cephalexin, Bactrim, Cipro, Ciprofloxacin, Levaquin, Keflex, Sulfamethoxazole, Minocycline, Lamisil, Nystatin, Levofloxacin, Bactrim DS, Cefdinir, Terbinafine, Tetracycline, Avelox, Sulfamethoxazole/Trimethoprim, Cefuroxime, Rocephin

Patients Can Self-Administer IV Antibiotics at Home: Study

Posted 25 Dec 2015 by Drugs.com

THURSDAY, Dec. 24, 2015 – Patients can be taught to safely self-administer long-term intravenous antibiotics at home, without the help of a health care worker, a new study suggests. The finding could have a significant impact on uninsured patients who might otherwise spend weeks in a hospital receiving IV care, according to researchers at the University of Texas Southwestern Medical Center at Dallas. "This really taps into human potential, giving a voice to the uninsured at the same time that it offers an opportunity for enormous cost savings to hospitals," study first author Dr. Kavita Bhavan, assistant professor of internal medicine, said in a medical center news release. Some infections require treatment with IV antibiotics for six weeks or more. Patients with insurance typically go home or to a nursing home and have their antibiotics administered by a home health care worker or ... Read more

Related support groups: Infections, Amoxicillin, Doxycycline, Bacterial Infection, Cephalexin, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Levaquin, Augmentin, Keflex, Zithromax, Trimethoprim, Sulfamethoxazole, Nitrofurantoin, Erythromycin, Clarithromycin, Minocycline, Levofloxacin

Health Tip: Understanding Antibiotics

Posted 9 Dec 2015 by Drugs.com

-- By taking an antibiotic as prescribed, you can get well faster and help prevent germs from becoming resistant to your medication. The U.S. Centers for Disease Control and Prevention offers these antibiotic guidelines: Never skip a dose of antibiotic. Always take it on schedule, as directed. Never stop taking an antibiotic early. Always take the entire prescription, unless your doctor tells you otherwise. Never save any antibiotic medication for a future illness. Never take an antibiotic that was prescribed for another person. Read more

Related support groups: Infections, Amoxicillin, Metronidazole, Doxycycline, Bacterial Infection, Cephalexin, Clindamycin, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Levaquin, Augmentin, Flagyl, Keflex, Zithromax, Valtrex, Trimethoprim, Sulfamethoxazole, Acyclovir

Antibiotics May Not Help After 'Complicated' Appendectomy

Posted 2 Nov 2015 by Drugs.com

MONDAY, Nov. 2, 2015 – Antibiotics may not reduce the risk of infections in patients who undergo what's known as a "complicated" appendix removal, a new study finds. "The traditional teaching is that all patients with complicated appendicitis receive post-operative antibiotics to reduce the risk of wound infection or deep organ space infection," study lead author Dennis Kim, of the Los Angeles Biomedical Research Institute, explained in an institute news release. But is that advisory warranted? To find out, Kim's team tracked five-year outcomes for 410 patients. All of the patients had complicated appendectomies, meaning that their appendix was found to be perforated or gangrenous. About two-thirds of the patients received antibiotics after surgery. Those who received antibiotics had no fewer infections, Kim's team said, and they stayed in hospital an average of one day longer than ... Read more

Related support groups: Amoxicillin, Doxycycline, Cephalexin, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Levaquin, Keflex, Zithromax, Sulfamethoxazole, Erythromycin, Clarithromycin, Minocycline, Levofloxacin, Bactrim DS, Cefdinir, Vancomycin, Tetracycline, Avelox

New Antibiotic-Resistant 'Superbug' an Emerging Threat, CDC Says

Posted 5 Oct 2015 by Drugs.com

MONDAY, Oct. 5, 2015 – A relatively new antibiotic-resistant bacteria called CRE is making inroads in some major American cities, U.S. health officials report. Surveillance of seven U.S. metropolitan areas found higher-than-expected levels of CRE in Atlanta, Baltimore and New York City, according to the U.S. Centers for Disease Control and Prevention. Lower-than-expected levels were found in Albuquerque, Denver and Portland, Ore., while the Minneapolis rate was what the agency anticipated. But CDC researchers were dismayed that they found active cases of CRE infection in every city they examined, said senior author Dr. Alexander Kallen, a CDC medical officer. The results support the CDC's decision to promote coordinated regional efforts to prevent the spread of CRE and other antibiotic-resistant germs, Kallen said. "Here we are with an opportunity to intervene on one of these ... Read more

Related support groups: Infections, Metronidazole, Bacterial Infection, Bactrim, Flagyl, Bacterial Skin Infection, Methicillin-Resistant Staphylococcus Aureus Infection, Bactrim DS, Sulfamethoxazole/Trimethoprim, Xifaxan, Polymyxin B, Skin and Structure Infection, Septra, Bacitracin, Metro, Rifaximin, SMZ-TMP DS, Septra DS, Sulfatrim, Chloramphenicol

Health Tip: Why Antibiotic Resistance Is Serious

Posted 16 Nov 2011 by Drugs.com

-- Antibiotic resistance occurs when a bacterium mutates and becomes immune to the effects of a specific antibiotic. You can help prevent antibiotic resistance by taking an antibiotic regimen only when necessary. Remember that antibiotics don't work against viral infections such as a cold or the flu. If you do begin taking an antibiotic, you should never skip a dose. Also, you should finish the entire amount that your doctor has prescribed, despite the fact that you might be feeling better. The U.S. Centers for Disease Control and Prevention says antibiotic-resistant bacteria are dangerous because: It may be difficult to find a medication that kills the bacteria. Resistant bacteria tend to spread more quickly between families and within communities. Infections become more difficult and more expensive to treat. People may die from a resistant infection before it can be treated ... Read more

Related support groups: Amoxicillin, Metronidazole, Doxycycline, Bacterial Infection, Cephalexin, Penicillin, Clindamycin, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Levaquin, Augmentin, Flagyl, Keflex, Zithromax, Trimethoprim, Sulfamethoxazole, Nitrofurantoin, Erythromycin

Research Warns of Overuse of Powerful Class of Antibiotics

Posted 3 Apr 2011 by Drugs.com

SUNDAY, April 3 – The use of a powerful class of antibiotics called carbapenems has increased dramatically in the United States over the past five years, a new study shows. The increased use of these drugs – widely regarded as the last option for treating severe infections caused by multidrug-resistant bacteria – is cause for concern because carbapenem-resistant bacteria are becoming more common, the researchers said. Overuse of carbapenem drugs could lead to the reduction of their effectiveness against tough-to-treat infections. For this study, the researchers analyzed antibiotic use in 110 VA facilities from 2005 to 2009. They found a gradual rise in overall antibiotic use, but major increases in the use of certain types of antibiotics: carbapenems (102 percent); intravenous vancomycin (79 percent); and combinations of penicillin with beta-lactamase-inhibitors (41 percent). The ... Read more

Related support groups: Ertapenem, Meropenem, Invanz, Merrem, Primaxin IM, Cilastatin/Imipenem, Merrem Novaplus, Primaxin IV, Doripenem, Doribax

Smarten Up About Antibiotics, CDC Urges

Posted 18 Nov 2010 by Drugs.com

THURSDAY, Nov. 18 – Knowing when to take antibiotics – and when not to – can help fight the rise of deadly "superbugs," say experts at the U.S. Centers for Disease Control and Prevention. About half of antibiotics prescribed are unnecessary or inappropriate, the agency says, and overuse has helped create bacteria that don't respond, or respond less effectively, to the drugs used to fight them. "Antibiotics are a shared resource that has become a scarce resource," said Dr. Lauri Hicks, a medical epidemiologist at the CDC. She's also medical director a of new program, Get Smart: Know When Antibiotics Work, that had its launch this week. "Everyone has a role to play in preventing the spread of antibiotic resistance," Hicks said. The stakes are high, said Dr. Arjun Srinivasan, CDC's associate director for health care-associated infection prevention programs. Almost every type of bacteria ... Read more

Related support groups: Infections, Amoxicillin, Metronidazole, Doxycycline, Cephalexin, Penicillin, Clindamycin, Azithromycin, Bactrim, Cipro, Ciprofloxacin, Fluconazole, Levaquin, Augmentin, Flagyl, Keflex, Zithromax, Trimethoprim, Sulfamethoxazole, Diflucan

Antibiotic Resistance Can Last a Year, Review Finds

Posted 19 May 2010 by Drugs.com

TUESDAY, May 18 – Some patients who take antibiotics may become resistant to them and stay that way for as long as a year, a new review finds. The researchers analyzed 24 studies of antibiotic resistance, in which people develop a partial or full immunity to the powers of a medication. The studies looked at use of the drugs in primary care, most often for respiratory or urinary tract infections. Antibiotic resistance is at its height in the month after a drug is prescribed, but the effect may last for a year, according to the findings published online May 18 in BMJ. "Primary care clinicians and patients may wish to consider this evidence when discussing the benefits and risks of prescribing and consuming antibiotics," study author Alastair Hay, consultant senior lecturer in primary health care at the University of Bristol in England, and colleagues concluded. In an accompanying ... Read more

Related support groups: Amoxicillin, Metronidazole, Doxycycline, Cephalexin, Penicillin, Bactrim, Cipro, Ciprofloxacin, Levaquin, Flagyl, Keflex, Trimethoprim, Sulfamethoxazole, Nitrofurantoin, Minocycline, Levofloxacin, Macrobid, Bactrim DS, Cefdinir, Vancomycin

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