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Chronic Granulomatous Disease News

First Drug, Nucala (Mepolizumab), Approved for Rare Eosinophilic Granulomatosis With Polyangiitis

Posted 12 Dec 2017 by Drugs.com

TUESDAY, Dec. 12, 2017 – Nucala (mepolizumab) has been approved by the U.S. Food and Drug Administration as the first remedy to treat adults with eosinophilic granulomatosis with polyangiitis, a rare autoimmune disease that leads to inflammation of the blood vessels. Other symptoms of the condition, formerly called Churg-Stress syndrome, include asthma and an overabundance of an infection-fighting white blood cell called an eosinophil. The inflamed blood vessels may affect the lungs, intestines, skin, heart and nervous system. The condition affects a total of about 11 out of every one million people in United States, the FDA said Tuesday in a news release. "Patients taking Nucala in clinical trials reported a significant improvement in their symptoms," said Dr. Badrul Chowdhury, director of the FDA's Division of Pulmonary, Allergy and Rheumatology Products. Nucala, a once-monthly ... Read more

Related support groups: Autoimmune Disorders, Nucala, Mepolizumab, Chronic Granulomatous Disease

U.S. Researchers Find New Way to Gauge Rare Genetic Condition

Posted 29 Dec 2010 by Drugs.com

WEDNESDAY, Dec. 29 – Federal researchers say they've gained insight into how to analyze the risks facing people with a rare immune system-weakening condition called chronic granulomatous disease, paving the way toward more personalized treatment. "Advances in treatment of CGD have made it possible for people with this once-fatal disease of early childhood to survive into adulthood; however, the disease remains difficult to manage," Dr. Anthony S. Fauci, director of the U.S. National Institute of Allergy and Infectious Diseases, said in a news release from the agency, which co-sponsored the research. "Having a marker to help predict disease prognosis will enable physicians to recommend treatment options that are more tailored to the needs of individual patients." The inherited disease causes people to become especially vulnerable to infections caused by certain germs and fungi, leading ... Read more

Related support groups: Chronic Granulomatous Disease

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Immunodeficiency

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interferon gamma-1b, Actimmune