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Prices of Generic Heart Failure Drugs Vary Widely

Posted 15 Nov 2016 by Drugs.com

TUESDAY, Nov. 15, 2016 – Cash prices of generic medicines to treat heart failure vary so widely that some patients may not be able to afford to fill all of their prescriptions, a new study suggests. In the greater St. Louis area, the cost of filling prescriptions for three common drugs – digoxin, lisinopril and carvedilol – ranged from as little as $12 to as much as $400 a month, the researchers found. Cardiologist Dr. Paul Hauptman, the study's lead author, said retail pricing is confusing and inconsistent. Patients "can encounter some major sticker shock," he said. The wide range of prices was unrelated to the drug dose or duration of therapy, the area where the pharmacy does business, whether it was a chain or independent pharmacy, or median income in pharmacy ZIP codes, the researchers noted. "There may be different reasons for different pricing practices, but this clearly needs ... Read more

Related support groups: Lisinopril, Heart Failure, Congestive Heart Failure, Carvedilol, Digoxin, Coreg, Left Ventricular Dysfunction, Hydrochlorothiazide/Lisinopril, Zestril, Coreg CR, Lanoxin, Zestoretic, Prinivil, Digitek, Prinzide, Qbrelis, Digox, Left Ventriculography, Cardoxin, Lanoxicaps

Device Plus 'Aggressive' Drug Strategy May Curb Severe Heart Failure

Posted 13 Nov 2016 by Drugs.com

SUNDAY, Nov. 13, 2016 – A combination of an implanted heart device and intensive drug therapy may help boost heart function in end-stage heart failure patients, preliminary results of an ongoing study suggest. The research focused on 36 patients who were implanted with what's known as a left ventricular assist device (LVAD), a kind of heart pump. "Patients who receive this assist device generally are in line to receive a heart transplant," explained cardiologist Dr. Michael Kim, who reviewed the new findings. "Because there are not nearly enough hearts available for transplantation relative to the need for heart transplantation, these newer assist devices can keep these sick patients alive until a heart does become available, sometimes for years," said Kim. He directs interventional cardiology at Lenox Hill Hospital in New York City. The new study was led by Dr. Emma Birks, professor ... Read more

Related support groups: Lisinopril, Losartan, Heart Failure, Congestive Heart Failure, Spironolactone, Carvedilol, Digoxin, Coreg, Cozaar, Hyzaar, Aldactone, Left Ventricular Dysfunction, Hydrochlorothiazide/Lisinopril, Zestril, Coreg CR, Lanoxin, Zestoretic, Prinivil, Hydrochlorothiazide/Losartan, Digitek

Statins Often Interact With Other Heart Drugs

Posted 17 Oct 2016 by Drugs.com

MONDAY, Oct. 17, 2016 – Cholesterol-lowering statins can interact with other drugs prescribed for heart disease. But there are ways to navigate the problem, according to new recommendations from the American Heart Association. Statins are among the mostly widely prescribed drugs in the United States. Roughly one-quarter of Americans age 40 and up are on a statin, according to a 2014 study by the U.S. Centers for Disease Control and Prevention. The drugs are prescribed to people who either have atherosclerosis (clogged arteries) or are at risk of it, which means many statin users also take other cardiovascular drugs, the heart association says. The benefits of those drug combinations will generally outweigh the risks, said Barbara Wiggins, a clinical pharmacy specialist in cardiology at the Medical University of South Carolina. But doctors and patients should be aware of how the drugs ... Read more

Related support groups: Warfarin, Coumadin, Amlodipine, Lipitor, Simvastatin, Crestor, Diltiazem, Atorvastatin, Norvasc, Pravastatin, Verapamil, Amiodarone, Digoxin, Nifedipine, Cardizem, Zocor, Azor, Lovastatin, Exforge, Rosuvastatin

Heart Drug Digoxin May Not Be Best for Some Heart Patients

Posted 5 May 2015 by Drugs.com

TUESDAY, May 5, 2015 – Taking the heart drug digoxin may increase the risk of premature death in patients with an irregular heartbeat and in those suffering from heart failure, German researchers report. In the review of published studies on the subject, patients treated with digoxin had a 21 percent increased risk of early death overall from any cause, compared with patients not taking the drug. Among patients with the irregular heart rhythm known as atrial fibrillation, researchers found a 29 percent greater risk of premature death, while the increased risk was 14 percent among heart failure patients. "Digoxin should be used with great caution," said lead researcher Dr. Stefan Hohnloser, a professor of cardiology at the J.W. Goethe University in Frankfurt. "There are better drugs for many patients, for instance in those who receive the drug for atrial fibrillation," he said, which ... Read more

Related support groups: Atrial Fibrillation, Arrhythmia, Heart Failure, Congestive Heart Failure, Digoxin, Multaq, Left Ventricular Dysfunction, Lanoxin, Dronedarone, Digitek, Asystole, Digox, Cardoxin, Lanoxicaps

Common Drug for Irregular Heartbeat Tied to Worse Outcomes

Posted 4 Mar 2015 by Drugs.com

WEDNESDAY, March 4, 2015 – Patients who take the heart rhythm drug digoxin may face a nearly 30 percent greater risk of death than patients not taking the drug, a review of prior research suggests. The analysis also suggests that digoxin may increase the risk for death by 60 to 70 percent among patients with both the heart rhythm disorder known as atrial fibrillation and kidney failure. The findings stem from an in-depth look at 19 studies involving nearly a half million atrial fibrillation patients, many of whom were prescribed digoxin (brand names: Digox, Lanoxin) as a way to rein in irregular heartbeats. "Between 15 to 20 percent of atrial fibrillation patients use this drug to control this disorder of the heart, which is very prevalent among older age groups," said study lead author Dr. Waqas Qureshi, a clinical and research fellow of cardiology at Wake Forest School of Medicine in ... Read more

Related support groups: Atrial Fibrillation, Digoxin, Lanoxin, Digitek, Digox, Cardoxin, Lanoxicaps

U.S. Prices Soaring for Some Generic Drugs, Experts Say

Posted 12 Nov 2014 by Drugs.com

WEDNESDAY, Nov. 12, 2014 – Market forces are dramatically driving up the cost of some generic drugs, prompting U.S. investigations into the pricing of what should be cheap alternatives to brand-name medications. Generics that should cost pennies per dose have undergone radical increases in price in recent years, said Dr. Aaron Kesselheim, author of a new commentary in the New England Journal of Medicine, and director of the Program on Regulation, Therapeutics and Law at Brigham and Women's Hospital in Boston. For example, the widely used broad-spectrum antibiotic doxycycline has increased from 6.3 cents to $3.36 per pill. And the long-established antidepressant drug clomipramine has increased from 22 cents to $8.32 per pill, Kesselheim noted in his commentary. Supply chain and manufacturing problems have caused some of these price hikes, he said. But Kesselheim believes that other ... Read more

Related support groups: Doxycycline, Digoxin, Anafranil, Clomipramine, Doryx, Oracea, Monodox, Doxy Lemmon, Lanoxin, Vibramycin, Adoxa, Doxy 100, Digitek, Vibra-Tabs, Digox, Doxy 200, Doxy-Caps, Adoxa CK, Oraxyl, Ocudox

Heart Medication Digoxin Linked to Higher Risk of Death for Some

Posted 11 Aug 2014 by Drugs.com

MONDAY, Aug. 11, 2014 – Digoxin, a drug that's been used to treat heart problems for about 200 years, might increase the risk of dying in certain patients. New research suggests that for people who have a particular type of irregular heart rhythm, called atrial fibrillation, taking the drug digoxin may increase the risk of dying by more than 20 percent. "We found in 122,000 patients with atrial fibrillation, those treated with digoxin were more likely to die [during the study period] than patients prescribed other medications," said lead researcher Dr. Mintu Turakhia, an assistant professor of cardiology at Stanford University School of Medicine in Palo Alto, Calif. Although the current research found an association between the drug digoxin and a higher risk of death for people with atrial fibrillation or flutter, the study does not show that the drug caused the higher risk of death. ... Read more

Related support groups: Atrial Fibrillation, Digoxin, Lanoxin, Digitek, Digox, Cardoxin, Lanoxicaps

A Cheap, Old Heart Drug May Help Elderly Heart Failure Patients

Posted 11 Mar 2013 by Drugs.com

MONDAY, March 11 – Everything old is new again, even in medicine, with a just-released study finding that an older, inexpensive drug may help keep heart failure patients out of the hospital. Largely abandoned after a 1997 study found that it did not lower heart failure patients' death rates, a re-analysis of that data found that digoxin (also known as digitalis) may lower rates of 30-day hospital readmissions by more than one-third. "If these findings can be replicated in contemporary older heart failure patients discharged from the hospital, digoxin may provide an inexpensive tool to reduce 30-day all-cause hospital readmissions," said study lead researcher Dr. Ali Ahmed, a professor of medicine and epidemiology in the divisions of geriatrics and cardiology at the University of Alabama at Birmingham. Ahmed presented the findings Monday in San Francisco at the annual meeting of the ... Read more

Related support groups: Heart Failure, Congestive Heart Failure, Digoxin, Lanoxin, Digitek, Cardoxin, Lanoxicaps

Heart Drug Digoxin Tied to Higher Death Risk for Some Patients

Posted 28 Nov 2012 by Drugs.com

WEDNESDAY, Nov. 28 – The widely used heart drug digoxin is associated with an increased risk of death in people with the common heart rhythm disorder know as atrial fibrillation, a new study finds. Researchers analyzed data from more than 4,000 patients with atrial fibrillation and found that digoxin was associated with a 41 percent increased risk of death from all causes, a 35 percent increased risk of death from cardiovascular causes, and a 61 percent increased risk of death from problems with the rate and rhythm of the heartbeat. The findings mean that among patients with atrial fibrillation who take taking digoxin – compared to those not taking digoxin – one additional patient out of six will die from any cause over five years, one additional patient out of eight will die from cardiovascular causes, and one additional patient out of 16 will die from arrhythmias, the study authors ... Read more

Related support groups: Atrial Fibrillation, Digoxin, Lanoxin, Digitek, Cardoxin, Lanoxicaps

Certain Heart Meds May Give Chemo a Boost

Posted 19 Jul 2012 by Drugs.com

WEDNESDAY, July 18 – When common heart drugs such as digitalis and digoxin are combined with some chemotherapy drugs, the effect appears to be an increase in the death of cancer cells, according to French researchers. These medications, called glycosides, have been around for decades and are used to treat heart failure and irregular heartbeats. When combined with chemotherapy drugs, however, they appear to act similar to a vaccine – priming the immune system to kill cancer cells. "This is very exciting; it describes a new way to make chemotherapy more effective," said Marc Symons, an investigator at the Center for Oncology and Cell Biology at the Feinstein Institute for Medical Research in Manhasset, N.Y. Symons was not involved in the study, which was published July 18 in the journal Science Translational Medicine. The effect was first noticed when the French team, led by Laurie ... Read more

Related support groups: Cancer, Digoxin, Lanoxin, Digitek, Cardoxin, Lanoxicaps

Accidental Medication Poisonings in Kids on the Rise

Posted 16 Sep 2011 by Drugs.com

FRIDAY, Sept. 16 – Despite ongoing prevention efforts, a growing number of young children are being accidentally poisoned with medications, according to new research. The study, which was based on data reported to the American Association of Poison Control Centers between 2001 and 2008, found that medication poisoning among children aged 5 and under increased by 22 percent, although the number of children in the United States in this age group rose by only 8 percent during the study period. "The problem of pediatric poisoning in the U.S. is getting worse, not better," Dr. Randall Bond, of Cincinnati Children's Hospital Medical Center, said in a hospital news release. In conducting the study, which is scheduled for publication in the Journal of Pediatrics, the researchers reviewed information on over 544,000 children who landed in the emergency department due to medication poisoning ... Read more

Related support groups: Xanax, Suboxone, Oxycodone, Hydrocodone, Methadone, Percocet, OxyContin, Klonopin, Vicodin, Lisinopril, Norco, Fentanyl, Clonazepam, Morphine, Ativan, Ambien, Valium, Metoprolol, Codeine, Lortab

FDA Medwatch Alert: Digoxin, USP 0.25 mg

Posted 12 May 2009 by Drugs.com

AS Medication Solutions, LLC, a drug repackage company, announced today that all tablets of Caraco brand Digoxin, USP, 0.25 mg, distributed prior to March 31, 2009, which are not expired and are within the expiration date of August, 2011, are being voluntarily recalled to the consumer level. The tablets are being recalled because they may differ in size and therefore could have more or less of the active ingredient, digoxin. Caraco Pharmaceutical Laboratories, Ltd manufactured the recalled tablets. The recalled product is a scored round biconvex white tablet imprinted with "441", with an NDC number of 54569-5758-0 (30-count). Consumers with the product that are within expiration should return these products to their pharmacy or place of purchase. [Posted 04/01/2009] Caraco Pharmaceutical Laboratories and FDA notified healthcare professionals of a consumer-level recall of Caraco brand ... Read more

Related support groups: Cardoxin

FDA Medwatch Alert: Digoxin, USP 0.125 mg, Digoxin, USP 0.25 mg (Caraco brand)

Posted 1 Apr 2009 by Drugs.com

[Posted 04/01/2009] Caraco Pharmaceutical Laboratories and FDA notified healthcare professionals of a consumer-level recall of Caraco brand Digoxin, USP, 0.125 mg, and Digoxin, USP, 0.25 mg, distributed prior to March 31, 2009, which are not expired and are within the expiration date of September, 2011. The tablets are being recalled because they may differ in size and therefore could have more or less of the active ingredient, digoxin, a drug product used to treat heart failure and abnormal heart rhythms. The drug has a narrow therapeutic index and the existence of higher than labeled dose may pose a risk of digoxin toxicity in patients with renal failure. Digoxin toxicity can cause nausea, vomiting, dizziness, low blood pressure, cardiac instability, and bradycardia. Death can also result from excessive digoxin intake. A lower than labeled dose may pose a risk of lack of efficacy ... Read more

Related support groups: Cardoxin

Heart Drug May Be a Cancer Fighter

Posted 7 Jan 2009 by Drugs.com

WEDNESDAY, Jan. 7 – Digoxin, a drug used for many years to treat irregular heart rhythms and heart failure, may also be a cancer-fighting agent, researchers report. Cancer cells need to create new blood vessels to survive. But many of these cells are oxygen-deprived and need to switch on genes that produce a protein called hypoxia-inducible factor (HIF-1), which help cells survive in low-oxygen conditions. Digoxin reduces HIF-1, causing cancer cells to die, the scientists from Johns Hopkins University found. "Anytime you see alternative uses for existing drugs, that always generates a certain amount of excitement," said William Phelps, director of preclinical and translational cancer research at the American Cancer Society. "In the cancer field, we are always looking for any new compounds, so this is an exciting potential." For the study, Dr. Gregg L. Semenza, director of the vascular ... Read more

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Atrial Fibrillation, Heart Failure, Congestive Heart Failure

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