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Can Fetal Alcohol Damage Be Undone?

Posted 19 hours ago by Drugs.com

WEDNESDAY, July 19, 2017 – Animal research may have yielded a potential treatment for fetal alcohol spectrum disorder in children. Two common medications reversed memory and learning problems in rats exposed to alcohol while in the womb, according to researchers at Northwestern University in Chicago. "We've shown you can interfere after the damage from alcohol is done. That's huge," study senior author Eva Redei said in a university news release. Currently, there is no treatment for fetal alcohol spectrum disorder, added Redei, a professor of psychiatric diseases affecting children and adolescents. In the United States, 1 percent to 5 percent of children are born with fetal alcohol spectrum disorder. The condition is linked with low IQ; learning, memory and behavioral problems; high risk of depression; and heart and other health problems. For 10 days after birth, rat pups that were ... Read more

Related support groups: Metformin, Levothyroxine, Synthroid, Alcohol Dependence, Glucophage, Levoxyl, Janumet, Alcoholism, Delivery, Levothroid, Eltroxin, Glucophage XR, Vitamin/Mineral Supplementation during Pregnancy/Lactation, Tirosint, ActoPlus Met, Euthyrox, Glumetza, Janumet XR, Glyburide/Metformin, Oroxine

Early Menopause May Be Tied to Type 2 Diabetes

Posted 19 hours ago by Drugs.com

WEDNESDAY, July 19, 2017 – The earlier a woman begins menopause, the greater her risk of developing diabetes, a new study suggests. Following almost 4,000 women in the Netherlands, Dutch researchers found that those who went through menopause before age 40 were almost four times as likely to develop type 2 diabetes as women whose menopause was late – at 55 or older. The average age for menopause in the United States is 51, according to the National Institute on Aging. Overall, the risk of developing diabetes fell 4 percent for each added year before menopause, according to the study. "Early onset of [natural menopause] is an independent marker for [type 2 diabetes] in postmenopausal women," wrote Dr. Taulant Muka and colleagues at Erasmus University Medical Center in Rotterdam. Their results were published July 18 in the journal Diabetologia. The study doesn't show a direct ... Read more

Related support groups: Diabetes, Type 2, Hot Flashes, Menopausal Disorders, Glipizide, Postmenopausal Symptoms, Insulin Resistance, Janumet, Glyburide, Pre-Diabetes, Glimepiride, Atrophic Vaginitis, Amaryl, Perimenopausal Symptoms, Diabetes Mellitus, Prandin, GlipiZIDE XL, Glucotrol, ActoPlus Met, Dyspareunia, Glucotrol XL

Broccoli Extract Shows Promise for Type 2 Diabetes

Posted 14 Jun 2017 by Drugs.com

WEDNESDAY, June 14, 2017 – Your Mom may have been right about broccoli's goodness. A small study hints that a substance in the crunchy veggy may help some with diabetes get better control of their blood sugar. Researchers found that a concentrated extract of the substance, called sulforaphane, helped obese type 2 diabetes patients rein in their stubbornly high blood sugar levels. The caveat, however, is that the study was short-term and small – involving 97 people with diabetes followed for 12 weeks. And the extract was taken in addition to the diabetes drug metformin, not instead of it. Plus, the extract the researchers used was not like the sulforaphane supplements available at your local health food store. "The way that you produce and process the extract is important to keep the sulforaphane intact," said senior researcher Dr. Anders Rosengren, of the University of Gothenburg, in ... Read more

Related support groups: Metformin, Melatonin, Glucophage, Fish Oil, Lovaza, Insulin Resistance, Janumet, Glucosamine, 5-HTP, Turmeric, Cranberry, Creatine, Garlic, Chondroitin, Valerian, St. John's Wort, Green Tea, Tryptophan, Lysine, CoQ10

Can Folks With Type 2 Diabetes Forgo the Finger Stick?

Posted 11 Jun 2017 by Drugs.com

SATURDAY, June 10, 2017 – People with type 2 diabetes who aren't taking insulin don't necessarily need to check their blood sugar levels, a new study contends. Many of these patients use "finger prick" blood sugar monitors, but "testing blood sugar didn't have any impact on their blood sugar," said study author Dr. Laura Young, an assistant professor of medicine at the University of North Carolina. "The best way to control blood sugar is to take your medication the way your doctor asks you to and to take good care of yourself," she said. "The key is really taking your medications." Monitoring might be helpful when starting a new medication or changing doses, Young said. "But if someone is on insulin, they absolutely need to be tested regularly," she said. Insulin predisposes people to have blood sugar that's too low, a condition called hypoglycemia. Hypoglycemia can cause dizziness and ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Glipizide, Glucophage, Insulin Resistance, Janumet, Invokana, Glyburide, Glimepiride, Amaryl, Diabetes Mellitus, Glucophage XR, Farxiga, GlipiZIDE XL, Glucotrol, Jardiance, ActoPlus Met, Glucotrol XL, Glumetza

Study Confirms Link Between SGLT2 inhibitors and Diabetic Ketoacidosis

Posted 7 Jun 2017 by Drugs.com

WEDNESDAY, June 7, 2017 – A new class of type 2 diabetes drugs called SGLT2 inhibitors could increase the risk of a rare, life-threatening complication of the disease called ketoacidosis, a new study warns. SGLT2 inhibitors include prescription medications such as canagliflozin, dapagliflozin and empagliflozin. Brand names are Invokana, Invokamet, Farxiga, Xigduo XR, Jardiance and Glyxambi. These drugs first became available in 2013, but in 2015 the U.S. Food and Drug Administration issued a warning about an increased risk for diabetic ketoacidosis when SGLT2 inhibitors are used. The condition typically occurs in people with type 1 diabetes. And while it is uncommon in people with type 2 diabetes, case reports have shown it can occur with type 2 disease, according to the study authors. Ketoacidosis can cause vomiting, abdominal pain, shortness of breath and swelling in the brain. Left ... Read more

Related support groups: Diabetes, Type 2, Diabetes, Type 1, Insulin Resistance, Invokana, Pre-Diabetes, Diabetes Mellitus, Farxiga, Jardiance, Diabetic Ketoacidosis (DKA), Glyxambi, Abnormal Glucose Tolerance, Canagliflozin, Xigduo XR, Synjardy, Qtern, Invokamet, Dapagliflozin, Synjardy XR, Dapagliflozin/metformin, Empagliflozin/metformin

Diabetes Drug Gets FDA Warning Due to Amputation Risk

Posted 17 May 2017 by Drugs.com

WEDNESDAY, May 17, 2017 – The type 2 diabetes prescription drug canagliflozin (brand names Invokana, Invokamet, Invokamet XR) appears to increase the risk of leg and foot amputations, the U.S. Food and Drug Administration now says. The FDA is requiring the medications to carry new warnings about the risk. The required warnings on the drug's labeling include the most serious and prominent boxed warning. The agency's decision is based on data from two large clinical trials showing that leg and foot amputations occurred about twice as often in patients taking canagliflozin as among those taking a placebo. Amputations of the toe and middle of the foot were the most common, but leg amputations below and above the knee also occurred. Some patients had more than one amputation, some had amputations involving both limbs, according to the FDA. Type 2 diabetes occurs when the body becomes ... Read more

Related support groups: Diabetes, Type 2, Diabetic Neuropathy, Insulin Resistance, Diabetic Nerve Damage, Invokana, Diabetes Mellitus, Canagliflozin, Invokamet, Canagliflozin/metformin, Invokamet XR

FDA Medwatch Alert: Canagliflozin (Invokana, Invokamet): Drug Safety Communication - Increased Risk of Leg and Foot Amputations

Posted 16 May 2017 by Drugs.com

ISSUE: Based on new data from two large clinical trials, the FDA has concluded that the type 2 diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) causes an increased risk of leg and foot amputations. FDA is requiring new warnings, including the most prominent Boxed Warning, to be added to the canagliflozin drug labels to describe this risk. Final results from two clinical trials – the CANVAS (Canagliflozin Cardiovascular Assessment Study) and CANVAS-R (A Study of the Effects of Canagliflozin on Renal Endpoints in Adult Participants With Type 2 Diabetes Mellitus) – showed that leg and foot amputations occurred about twice as often in patients treated with canagliflozin compared to patients treated with placebo, which is an inactive treatment. Amputations of the toe and middle of the foot were the most common; however, amputations involving the leg, below and above the kne ... Read more

Related support groups: Diabetes, Type 2, Invokana, Canagliflozin, Invokamet, Canagliflozin/metformin, Invokamet XR

Intensive Treatment Shows Potential Against Type 2 Diabetes

Posted 15 Mar 2017 by Drugs.com

WEDNESDAY, March 15, 2017 – Instead of managing type 2 diabetes as a chronic condition, what if people could beat the disease? That was the thinking behind a small pilot study, which suggested that intensive treatment with oral medicine, insulin, diet and exercise might knock out the disease, at least for several months, in certain patients. Up to 40 percent of patients who were treated experienced complete or partial remission for three months, the study found. "We are now able to possibly reverse diabetes, and that really motivates patients to do their best in terms of losing weight and making sure their sugars are normalized," said lead author Dr. Natalia McInnes. She's an assistant professor of endocrinology and metabolism at McMaster University in Ontario, Canada. However, relatively few participants remained in remission a year later, diabetes experts noted. "Rates of diabetes ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Glucophage, Insulin Resistance, Janumet, Diabetes Mellitus, Glucophage XR, ActoPlus Met, Acarbose, Glumetza, Janumet XR, Glyburide/Metformin, Jentadueto, Glucovance, Avandamet, Abnormal Glucose Tolerance, Metformin/Pioglitazone, Kombiglyze XR, Fortamet

Dealing With Diabetes Distress

Posted 16 Feb 2017 by Drugs.com

THURSDAY, Feb. 16, 2017 – People with diabetes have to think about their condition and make treatment decisions constantly – and all that extra work and worry can lead to psychological distress at times. "Diabetes distress" isn't the same as depression, however, diabetes experts note. It's a condition unique to the 24/7 demands that come with diabetes, particularly for people dependent on insulin. "The day you develop diabetes, it's like the universe just handed you a new full-time job that you have to do in addition to whatever else you're doing. It's a special job that has a big impact on the rest of your life. There's no pay and no vacation," said William Polonsky, president of the Behavioral Diabetes Institute in San Diego. Alicia McAuliffe-Fogarty, vice president of lifestyle management at the American Diabetes Association, put it this way: "Diabetes distress is the extra burden ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Diabetes, Type 1, Glipizide, Glucophage, Novolog, Humalog, Insulin Resistance, Janumet, Invokana, Glyburide, Lantus Solostar, Levemir, Actos, Pre-Diabetes, Glimepiride, Novolin R, Amaryl

Is There a Link Between Diabetes and Pancreatic Cancer?

Posted 31 Jan 2017 by Drugs.com

TUESDAY, Jan. 31, 2017 – Developing or worsening type 2 diabetes could be an early sign of pancreatic cancer, new research suggests. Researchers analyzed data from nearly a million patients with type 2 diabetes or pancreatic cancer in Italy and Belgium. Half of all pancreatic cancer cases were diagnosed within a year of patients being diagnosed with diabetes, the findings showed. The investigators also found that type 2 diabetes patients whose condition deteriorated rapidly requiring more aggressive treatment were also at increased risk for pancreatic cancer. The study findings, which don't prove an association between type 2 diabetes and pancreatic cancer, were presented Monday at the European Cancer Congress (ECC) in Amsterdam. Research presented at medical meetings is typically considered preliminary until published in a peer-reviewed journal. "Doctors and their diabetic patients ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Glucophage, Glipizide, Novolog, Humalog, Janumet, Glyburide, Lantus Solostar, Levemir, Glimepiride, Pancreatic Cancer, Novolin R, Amaryl, Novolin N, Humulin N, Lantus Solostar Pen, Glucophage XR

Insulin Makers Conspired to Raise Prices: Lawsuit

Posted 31 Jan 2017 by Drugs.com

Three makers of insulin conspired to boost the prices of the lifesaving diabetes drug, according to a lawsuit filed Monday in federal court in Massachusetts. A recent study in the Journal of the American Medical Association said the price of insulin nearly tripled between 2002 and 2013, and three manufacturers – Sanofi, Novo Nordisk and Eil Lilly – have raised the list prices of their insulin in near unison, The New York Times reported. The price increases have triggered anger among patient groups and doctors, who say the rising cost of insulin appears to have little to do with higher production costs. "People who have to pay out of pocket for insulin are paying enormous prices, when they shouldn't be," Steve Berman, a lawyer for the patients, told The Times. The lawsuits alleges that the three companies increased the list prices on their insulin in order to win favor with pharmacy ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Diabetes, Type 1, Glucophage, Glipizide, Novolog, Humalog, Insulin Resistance, Janumet, Glyburide, Lantus Solostar, Levemir, Actos, Pre-Diabetes, Glimepiride, Novolin R, Amaryl, Novolin N

Language Barrier May Keep Some Hispanics From Good Diabetes Care

Posted 23 Jan 2017 by Drugs.com

MONDAY, Jan. 23, 2017 – Hispanic-American type 2 diabetes patients who lack proficiency in English may end up with poorer care, a new study finds. Specifically, these patients were found to be much less likely than non-Hispanic patients to take newly prescribed diabetes medications as directed, the researchers said. The study "suggests that more needs to be done to improve adherence to newly prescribed medications among Latino patients at all levels of English proficiency," wrote a team led by Dr. Alicia Fernandez, of the University of California, San Francisco. A diabetes specialist who reviewed the study wasn't surprised by the results. The research "further validates what many clinicians already know: Patients who do not understand English tend to do worse with management of chronic disease," said Dr. Maria Pena. She is an endocrinologist who directs the Center for Weight Management ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Diabetes, Type 1, Glucophage, Glipizide, Novolog, Humalog, Insulin Resistance, Janumet, Invokana, Glyburide, Lantus Solostar, Levemir, Actos, Pre-Diabetes, Glimepiride, Novolin R, Amaryl

Native Americans Make Progress Against Diabetes Complication

Posted 10 Jan 2017 by Drugs.com

TUESDAY, Jan. 10, 2017 – Diabetes-related kidney failure among Native American adults fell by more than half over almost 20 years, a U.S. Centers for Disease Control and Prevention report shows. The change is due to improvements in diabetes and kidney care, according to the report. The new research also found that among these patients, blood sugar control improved 10 percent between 1996 and 2014, and the use of medicine to protect kidneys rose from 42 percent to 74 percent over 5 years. Average blood pressure in Native Americans with diabetes and high blood pressure was well controlled (133/76 in 2015), the findings showed. In addition, more than 60 percent of Native Americans aged 65 and older with diabetes had a urine test for kidney damage in 2015, compared with 40 percent of Medicare patients with diabetes in 2013, the researchers said. "The Indian Health Service (IHS) has made ... Read more

Related support groups: Diabetes, Type 2, Metformin, Insulin, Lantus, Renal Failure, Glucophage, Glipizide, Novolog, Humalog, Insulin Resistance, Janumet, Glyburide, Lantus Solostar, Levemir, Pre-Diabetes, Glimepiride, Chronic Kidney Disease, Novolin R, Amaryl, Novolin N

Metformin Still Best Choice for First Type 2 Diabetes Treatment

Posted 3 Jan 2017 by Drugs.com

MONDAY, Jan. 2, 2017 – Newly updated guidelines reaffirm that metformin is the first-line drug for people with type 2 diabetes, and that several other medications – including newer ones – can be added if needed. The recommendations come from the American College of Physicians (ACP). The American Academy of Family Physicians endorsed the new guidelines. The ACP updated the guidelines because of new research into diabetes drugs, and the U.S. Food and Drug Administration approval of new diabetes drugs. "Metformin, unless contraindicated, is an effective treatment strategy because it has better effectiveness, is associated with fewer adverse effects, and is cheaper than most other oral medications," ACP president Dr. Nitin Damle said in a college news release. "The escalating rates of obesity in the U.S. are increasing the incidence and prevalence of diabetes substantially. Metformin has ... Read more

Related support groups: Diabetes, Type 2, Metformin, Januvia, Glipizide, Glucophage, Janumet, Invokana, Glyburide, Actos, Pre-Diabetes, Glimepiride, Amaryl, Pioglitazone, Tradjenta, Avandia, Glucophage XR, Farxiga, GlipiZIDE XL, Glucotrol, Jardiance

FDA Approves Invokamet XR (Canagliflozin/Metformin Hydrochloride Extended-Release) for the Treatment of Adults with Type 2 Diabetes

Posted 22 Sep 2016 by Drugs.com

RARITAN, N.J., September 21, 2016 – Janssen Pharmaceuticals, Inc. (Janssen) announced today the U.S. Food and Drug Administration (FDA) has approved Invokamet XR - a once-daily, fixed-dose combination therapy of canagliflozin and metformin hydrochloride extended-release (XR)—for first-line use as an adjunct to diet and exercise to improve blood glucose control in adults with type 2 diabetes when treatment with the two medications is appropriate.[1] Invokamet XR combines Invokana (canagliflozin), the most prescribed sodium glucose co-transporter 2 (SGLT2) inhibitor, with more than 9 million U.S. prescriptions since launch,[2] and an XR formulation of metformin. Metformin is commonly prescribed as an initial therapy for the treatment of type 2 diabetes. “Invokamet XR offers the convenience of once-daily dosing and provides physicians needed flexibility for tailoring treatment to the needs ... Read more

Related support groups: Diabetes, Type 2, Metformin, Invokana, Canagliflozin, Invokamet, Canagliflozin/metformin

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Invokamet, Invokamet XR

Canagliflozin / metformin Patient Information at Drugs.com