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Psychiatric Drugs May Reduce Ex-Prisoners' Violent Crime Rate

Posted 2 Nov 2016 by Drugs.com

TUESDAY, Nov. 1, 2016 – Released prisoners may be less likely to commit violent crimes if they're prescribed certain kinds of psychiatric medications, a new study suggests. These medications can affect someone's mental state. They include antidepressants, antipsychotics, psychostimulants, drugs to treat addiction and antiepileptic drugs, the researchers said. The study authors looked at information on more than 22,000 prisoners in Sweden. They were released between July 2005 and December 2010. The researchers had a median of nearly five years of follow-up information. During that time, 18 percent of the prisoners committed violent crimes, the researchers said. Three classes of drugs were linked to much lower rates of violent crimes. Antipsychotics were tied to a 42 percent reduction in violent crimes. For psychostimulants, the reduction was 38 percent. Drugs to treat addiction were ... Read more

Related support groups: Depression, Anxiety, Anxiety and Stress, Lexapro, Zoloft, Wellbutrin, Prozac, Paxil, Citalopram, Seroquel, Major Depressive Disorder, Celexa, Abilify, Sertraline, Lithium, Amitriptyline, Viibryd, Fluoxetine, Bupropion, Schizophrenia

U.S. FDA Approves Labeling Update of Rexulti (brexpiprazole) for Maintenance Treatment of Schizophrenia

Posted 29 Sep 2016 by Drugs.com

Princeton, New Jersey and Valby, Denmark – September 23, 2016 – Otsuka Pharmaceutical Development & Commercialization, Inc. (Otsuka) and H. Lundbeck A/S (Lundbeck) announced today that the U.S. Food and Drug Administration (FDA) approved the labeling update of Rexulti (brexpiprazole) to reflect clinical data for maintenance treatment of schizophrenia. The approval was based on results from a long-term randomized withdrawal trial in adults with schizophrenia aged 18 to 65 years. "There are approximately 2.4 million adults in the U.S. with schizophrenia[1] and 75% of patients[2] experience relapses where their symptoms return or worsen,” said Dr. Christoph U. Correll, professor of psychiatry, Hofstra Northwell School of Medicine and medical director, Recognition and Prevention Program (RAP), Zucker Hillside Hospital, both in New York. “These data, as included in the product labeling, confi ... Read more

Related support groups: Schizophrenia, Rexulti, Brexpiprazole

Antipsychotic Meds Pose Little Danger to Fetus, Study Finds

Posted 17 Aug 2016 by Drugs.com

WEDNESDAY, Aug. 17, 2016 – Taking antipsychotic medicines in early pregnancy does not significantly increase the risk of birth defects, a new study finds. "In general, the use of any medication should be avoided during pregnancy [if possible]," explained study co-author Krista Huybrechts of Brigham and Women's Hospital in Boston. "However, for women suffering from schizophrenia, bipolar disorder, or major depressive disorder, avoiding medication use is often impossible, given that there are very few alternative treatment options," she said in a hospital news release. But how safe is exposure to these drugs for the developing fetus? To find out, Huybrecht's team tracked Medicaid data on 1.3 million pregnant women in order to assess the effects of older (typical) antipsychotic drugs and newer (atypical) versions, which are less likely to affect fertility. The study focused on the most ... Read more

Related support groups: Birth Control, Depression, Contraception, Bipolar Disorder, Seroquel, Major Depressive Disorder, Abilify, Schizophrenia, Latuda, Risperdal, Risperidone, Schizoaffective Disorder, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Olanzapine, Psychiatric Disorders, Invega

'Managing' Elderly Patients Without Powerful Antipsychotics

Posted 26 Jul 2016 by Drugs.com

MONDAY, July 25, 2016 – About 25 percent of dementia patients in U.S. nursing homes are still quieted with risky antipsychotic medications. Now, a small study suggests that managing these difficult patients, instead of medicating them, could obtain better results. "Drugs have a place, but should not be first-line treatments. They don't work well, and there are side effects," said study author Dr. Henry Brodaty, a professor of aging and mental health at the University of New South Wales in Sydney, Australia. Antipsychotic drugs such as Risperdal (risperidone), Abilify (aripiprazole) and Seroquel (quetiapine) are approved to treat serious psychiatric conditions such as bipolar disorder and schizophrenia. But in seniors, they're often used to calm aggressive or violent behavior linked to dementia. "They're basically a sedative," said Dean Hartley, director of science initiatives with the ... Read more

Related support groups: Bipolar Disorder, Seroquel, Abilify, Mania, Schizophrenia, Latuda, Risperdal, Risperidone, Dementia, Schizoaffective Disorder, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Alzheimer's Disease, Olanzapine, Invega, Clozapine, Compazine

Antipsychotics Don't Ease Delirium in Hospitalized Patients

Posted 29 Mar 2016 by Drugs.com

TUESDAY, March 29, 2016 – Antipsychotic medications, such as haloperidol (Haldol) or clozapine (Clozaril), aren't appropriate for preventing or routinely treating delirium in hospitalized patients, a new study suggests. The researchers reviewed past studies and found that antipsychotic drugs given before surgery didn't prevent delirium. These drugs also didn't make any difference in the course of delirium in medical or surgical patients, the study authors said. "The American Geriatrics Society guidelines suggest avoiding using these medications as a part of routine care of a patient with delirium," said lead researcher Dr. Karin Neufeld, clinical director of psychiatry at Johns Hopkins Bayview Medical Center in Baltimore. Delirium causes confused thinking and diminished awareness of the environment, such as time and place. Delirium is often caused by physical or mental illness, such as ... Read more

Related support groups: Seroquel, Abilify, Lithium, Latuda, Risperdal, Risperidone, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Olanzapine, Haldol, Psychiatric Disorders, Invega, Clozapine, Compazine, Aripiprazole, Rexulti, Haloperidol

Schizophrenia Tied to Much Higher Risk of Suicide Attempts

Posted 19 Feb 2016 by Drugs.com

THURSDAY, Feb. 18, 2016 – Schizophrenia patients are at significantly increased risk of attempting suicide, a new study finds. Researchers analyzed data from more than 21,700 Canadians, including 101 who had been diagnosed with schizophrenia. About 39 percent of people (two in five) with schizophrenia had attempted suicide, compared with about 3 percent of people without the mental health disorder. "Even after taking into account most of the known risk factors for suicide attempts, those with schizophrenia had six times the odds of having attempted suicide in comparison to those without schizophrenia," study author Esme Fuller-Thomson said in a University of Toronto news release. Fuller-Thomson is a professor of social work at the university. When researchers focused only on the 101 individuals with schizophrenia, they found that "women and those with a history of drug or alcohol abuse ... Read more

Related support groups: Depression, Wellbutrin, Seroquel, Major Depressive Disorder, Abilify, Lithium, Amitriptyline, Viibryd, Bupropion, Schizophrenia, Wellbutrin XL, Remeron, Mirtazapine, Latuda, Risperdal, Risperidone, Elavil, Nortriptyline, Schizoaffective Disorder, Geodon

Drug Helps Those With Tough-to-Treat Schizophrenia: Study

Posted 25 Nov 2015 by Drugs.com

WEDNESDAY, Nov. 25, 2015 – The drug clozapine reduces symptoms in schizophrenia patients who don't benefit from other antipsychotic medications, a new study indicates. The finding, culled from an analysis of Medicaid data on more than 6,200 patients with treatment-resistant schizophrenia, was published recently in the American Journal of Psychiatry. "These results give clinicians important guidance for how to help an extremely vulnerable group of people," said study author Dr. T. Scott Stroup, a professor of psychiatry at Columbia University Medical Center in New York City and a research psychiatrist at New York State Psychiatric Institute. "By helping individuals with treatment-resistant schizophrenia get effective treatment sooner, we can expect better outcomes," Stroup said in a Columbia news release. Antipsychotic drugs relieve symptoms in most people with schizophrenia, but up to ... Read more

Related support groups: Seroquel, Abilify, Schizophrenia, Latuda, Risperdal, Risperidone, Schizoaffective Disorder, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Agitation, Psychosis, Olanzapine, Psychiatric Disorders, Invega, Clozapine, Aripiprazole, Rexulti

Many Seniors Given Antipsychotic Meds, Despite Potential Problems

Posted 21 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 21, 2015 – Antipsychotic drug use in American seniors increases with age, a new study cautions. The researchers found that the percentage of people aged 80 to 84 who received a prescription for an antipsychotic drug was twice that of people aged 65 to 69. This increase is occurring despite the known risks of serious side effects such as stroke, kidney damage, and death, they added. "The results of the study suggest a need to focus on new ways to treat the underlying causes of agitation and confusion in the elderly," study author Dr. Mark Olfson, from the College of Physicians and Surgeons and Columbia University in New York City, said in a news release from the U.S. National Institute of Mental Health (NIMH). "The public health community needs to give greater attention to targeted environmental and behavioral treatments rather than medications," he added. The ... Read more

Related support groups: Seroquel, Abilify, Lithium, Latuda, Risperdal, Risperidone, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Olanzapine, Haldol, Invega, Clozapine, Compazine, Aripiprazole, Rexulti, Haloperidol, Prochlorperazine

Brain Inflammation May Be Linked to Schizophrenia

Posted 16 Oct 2015 by Drugs.com

FRIDAY, Oct. 15, 2015 – Researchers say they've found a link between brain inflammation and schizophrenia. British investigators used PET scans to assess immune cell activity in the brains of 56 people. Some had schizophrenia, some were at risk for the mental disorder, and others had no symptoms or risk of the disease. The results showed that immune cells are more active in the brains of people with schizophrenia and those at risk for the disease. "Our findings are particularly exciting because it was previously unknown whether these cells become active before or after onset of the disease," lead author Peter Bloomfield, of the Medical Research Council's Clinical Sciences Center at Imperial College London, said in a college news release. "Now we have shown this early involvement, mechanisms of the disease and new medications can hopefully be uncovered," he added. The findings could ... Read more

Related support groups: Seroquel, Abilify, Lithium, Schizophrenia, Latuda, Risperdal, Risperidone, Schizoaffective Disorder, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Oppositional Defiant Disorder, Agitation, Psychosis, Olanzapine, Haldol, Invega, Agitated State

ERs Often 'Safety Net' Care for People With Schizophrenia: CDC

Posted 23 Sep 2015 by Drugs.com

WEDNESDAY, Sept. 23, 2015 – A new report finds that, too often, under-medicated Americans suffering from schizophrenia end up seeking care in the nation's hospital emergency rooms. The report, issued Wednesday by the U.S. Centers for Disease Control and Prevention, found that between 2009 and 2011, over 382,000 visits to ERs were recorded for people aged 18 to 64 with schizophrenia. Many of these cases involved people on Medicaid who were either homeless or living in places such as nursing homes or group homes, the researchers said. Emergency departments "may serve as a safety net for schizophrenic patients not otherwise receiving care," said Dr. Michael Albert and Linda McCaig, both of whom work at the CDC's National Center for Health Statistics (NCHS). Mental health expert Dr. Michael Birnbaum said the new findings were "not surprising." "Unfortunately many people with mental illness ... Read more

Related support groups: Seroquel, Abilify, Lithium, Schizophrenia, Latuda, Risperdal, Risperidone, Schizoaffective Disorder, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Psychosis, Olanzapine, Haldol, Invega, Clozapine, Compazine, Aripiprazole

Drug May Calm Agitation in Alzheimer's Patients

Posted 22 Sep 2015 by Drugs.com

TUESDAY, Sept. 22, 2015 – A drug that combines a cough suppressant with a heart medication might offer a safer option for calming the agitation that commonly affects people with Alzheimer's disease, an early clinical trial suggests. The study, of 220 Alzheimer's patients, found that the drug – called Nuedexta – generally eased agitation symptoms over 10 weeks. And it did not worsen patients' problems with memory, thinking and judgment, researchers reported in the Sept. 22/29 issue of the Journal of the American Medical Association. As Alzheimer's disease progresses, people often go through periods of agitation that can range from restlessness and pacing to aggressive behavior like yelling, fighting and destroying objects. If those issues can be managed without medication, that's always best, said Dr. Sam Gandy, a professor of neurology and psychiatry at Mount Sinai Hospital, in New ... Read more

Related support groups: Bipolar Disorder, Seroquel, Abilify, Schizophrenia, Latuda, Risperdal, Risperidone, Schizoaffective Disorder, Geodon, Zyprexa, Saphris, Quetiapine, Seroquel XR, Alzheimer's Disease, Agitation, Olanzapine, Invega, Agitated State, Clozapine, Aripiprazole

Rexulti Approved for Schizophrenia, Depression

Posted 13 Jul 2015 by Drugs.com

MONDAY, July 13, 2015 – Rexulti (brexpiprazole) has been approved by the U.S. Food and Drug Administration to treat schizophrenia, and as an add-on drug for major depressive disorder (MDD) when a first-line drug fails to effectively treat symptoms. Schizophrenia is a chronic, disabling brain disorder that primary affects people aged 30 and younger. Affecting about 1 percent of Americans, the disorder is characterized by hearing voices, believing other people are reading your mind, withdrawal and suspicion. MDD, commonly called depression, is characterized by unhappy mood that interferes with a person's ability to carry on life's daily activities. Other symptoms may include loss of interest in daily life, weight change, insomnia, restlessness, fatigue, feeling guilty or worthless, and inability to concentrate. Clinical studies evaluating the drug for both disorders involved more than ... Read more

Related support groups: Depression, Major Depressive Disorder, Schizophrenia, Rexulti, Brexpiprazole

U.S. FDA Approves New Drug Rexulti for Schizophrenia, Major Depression

Posted 13 Jul 2015 by Drugs.com

MONDAY, July 13, 2015 – A new drug to treat schizophrenia and depression has been approved by the U.S. Food and Drug Administration. Rexulti (brexpiprazole) tablets can be used to treat adults with schizophrenia. The new drug can also be used as an add-on therapy to antidepressant drugs for adults with major depression. "Schizophrenia and major depressive disorder can be disabling and can greatly disrupt day-to-day activities," Dr. Mitchell Mathis, director of the Division of Psychiatry Products in the FDA's Center for Drug Evaluation and Research, said in an agency news release. "Medications affect everyone differently so it is important to have a variety of treatment options available for patients with mental illnesses," he added. The FDA's approval of Rexulti for treatment of schizophrenia is based on two six-week clinical trials with more than 1,300 people. People taking the drug ... Read more

Related support groups: Depression, Major Depressive Disorder, Schizophrenia, Rexulti, Brexpiprazole

FDA Approves Rexulti (brexpiprazole) for Schizophrenia and Adjunctive Treatment for Major Depressive Disorder

Posted 11 Jul 2015 by Drugs.com

Tokyo, Japan and Valby, Denmark – July 11, 2015 –Otsuka Pharmaceutical Co., Ltd. (Otsuka) and H. Lundbeck A/S (Lundbeck) announced today that the U.S. Food and Drug Administration (FDA) approved Rexulti (brexpiprazole) as an adjunctive therapy for the treatment of adults with major depressive disorder (MDD) and as a treatment for adults with schizophrenia. Rexulti was discovered by Otsuka and co-developed with Lundbeck. It will be co-marketed by the two companies and is expected to become available to patients in the U.S. in early August 2015. The mechanism of action of Rexulti in the treatment of MDD or schizophrenia is unknown. However, the efficacy of Rexulti may be mediated through a combination of partial agonist activity at serotonin 5-HT1A and dopamine D2 receptors, and antagonist activity at serotonin 5-HT2A receptors. In addition, Rexulti exhibits high affinity (subnanomolar) ... Read more

Related support groups: Depression, Major Depressive Disorder, Schizophrenia, Rexulti, Brexpiprazole

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