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Bile Acid Synthesis Disorders News

Liver Fluke Parasite May Threaten Lives of Hundreds of Vietnam War Veterans

Posted 22 Nov 2017 by Drugs.com

A tropical parasite may be slowly killing hundreds of U.S. veterans of the Vietnam War. Early this year, the Department of Veterans Affairs commissioned a small pilot study to investigate the link between liver flukes ingested through raw or undercooked fish and a rare bile duct cancer called cholangiocarcinoma, the Associated Press reported. Symptoms can take decades to appear and by the time they do, many patients are in extreme pain and only a few months to live. Of the 50 blood samples from Vietnam veterans submitted for the study, more than 20 percent came back positive or near-positive for liver fluke antibodies, the AP reported. "It was surprising," said Sung-Tae Hong, the tropical medicine specialist who conducted the tests at Seoul National University in South Korea. He noted that these are preliminary findings that could include false positives and that the research is ... Read more

Related support groups: Hepatocellular Carcinoma, Liver and Pancreatic Disease, Clornorchis sinensis (Liver Fluke), Bile Acid Synthesis Disorders

Chemo Drug, Xeloda, May Buy Time for Those With Bile Duct Cancer

Posted 19 May 2017 by Drugs.com

THURSDAY, May 18, 2017 – The chemotherapy drug Xeloda may prolong survival in those struck by a type of digestive system cancer, a new study finds. People with bile duct cancer who received the medication lived for an average of about 17 months longer than those who didn't take it, the researchers found. Based on the findings, the study authors suggested that Xeloda should be given routinely to patients with this disease. Bile duct cancer – which occurs in an area that connects the liver, gallbladder and the small intestine – is rare and aggressive. It affects an estimated 8,000 people in the United States each year, according to the American Cancer Society. A statement from Cancer Research UK, which funded the new study, said it's difficult to study treatments for bile duct cancer because so few patients are available to take part in clinical trials. For the study, researchers gave ... Read more

Related support groups: Cancer, Xeloda, Bile Acid Synthesis Disorders

Cholbam Approved for Rare Metabolic Disorders

Posted 23 Mar 2015 by Drugs.com

WEDNESDAY, March 18, 2015 – Cholbam (cholic acid) capsules have been approved by the U.S. Food and Drug Administration to treat adults and children with bile acid synthesis disorders and peroxisomal disorders, the agency said in a news release. People with these rare disorders lack enzymes to process cholic acid, normally made by the liver from cholesterol. This leads to reduced bile flow, potentially poisonous buildup of bile acid products in the liver and less absorption of fats and vitamins. Left untreated, the disorders could cause deadly liver damage, the FDA said. Cholbam is sanctioned for adults and children aged 3 weeks and older. The drug was evaluated in clinical studies involving some 79 people aged 3 weeks to 36 years. Two-thirds of people with bile synthesis disorders treated with the drug survived longer than three years. And 42 percent of people with peroxisomal ... Read more

Related support groups: Bile Acid Synthesis Disorders

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Further Information

Related Condition Support Groups

Liver and Pancreatic Disease

Related Drug Support Groups

cholic acid, Cholbam