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Study Identifies Genetic Subtypes of Crohn's Disease

Posted 14 Oct 2016 by Drugs.com

FRIDAY, Oct. 14, 2016 – Crohn's disease appears to have at least two distinct genetic subtypes, which could explain why the condition is so hard to treat, a new study suggests. "The one-treatment-fits-all approach doesn't seem to be working for Crohn's patients," said study co-senior author Dr. Shehzad Sheikh. He's an assistant professor in the departments of medicine and genetics at the University of North Carolina School of Medicine. "It's plausible that this is because only a subset of patients has the type of disease that responds to standard therapy, whereas, for the rest of the patients, we're really not hitting the right targets," Sheikh said in a university news release. Crohn's is a chronic inflammatory disorder of the intestinal tract. The most common symptoms are diarrhea, stomach cramps and weight loss. The course and severity of the disease vary widely from patient to ... Read more

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Stem Cell Transplants May Not Help Tough-to-Treat Crohn's, Study Says

Posted 15 Dec 2015 by Drugs.com

TUESDAY, Dec. 15, 2015 – Stem cell transplants seem no better than conventional therapy for Crohn's disease that hasn't responded to other treatments, a new study finds. The European study also found that for patients who cannot undergo surgery for the condition, stem cell transplants resulted in serious side effects, including infections. "In this group of the most resistant cases of Crohn's disease, stem cell transplant was an effective treatment, but it is not a miracle cure that could be applied to anyone with Crohn's disease, because it only seems to work in a minority of patients and the treatment is challenging and hazardous," said lead researcher Christopher Hawkey. He is a professor of gastroenterology at Queen's Medical Centre in Nottingham, England. For the study, Hawkey and colleagues randomly assigned 45 patients with Crohn's disease to transplants with their own stem ... Read more

Related support groups: Crohn's Disease, Asacol, Crohn's Disease - Maintenance, Sulfasalazine, Pentasa, Lialda, Crohn's Disease - Acute, Apriso, Canasa, Mesalamine, Azulfidine, Asacol HD, Delzicol, Diagnosis and Investigation, Sulfazine, Rowasa, Canasa Pac, Salofalk, FIV-ASA, Mesasal Enteric Coated

Crohn's Disease Treatments for Kids May Not Get Gut Back to Normal

Posted 14 Oct 2015 by Drugs.com

WEDNESDAY, Oct. 14, 2015 – Current therapies for children with Crohn's disease don't fully restore healthy bacteria and fungi populations in their digestive systems, a new study shows. These findings suggest that treatments don't have to bring bacteria and other microbe levels back to normal levels in the gut to be useful. This knowledge could lead to new approaches for diagnosing and treating inflammatory bowel disease, according to the Oct. 14 study in the journal Cell Host & Microbe. "We show that microbes in the gut respond to treatment of inflammatory bowel disease in a much more complex way than has been previously appreciated," co-principal investigator Gary Wu, from the University of Pennsylvania in Philadelphia, said in a journal news release. "The results of our study provide information that could be used to track or predict disease, as well as new diet-based therapeutic ... Read more

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Ulcerative Colitis, Crohn's Disease, Crohn's Disease - Maintenance, Ulcerative Colitis - Active, Ulcerative Colitis - Maintenance, Inflammatory Bowel Disease, Ulcerative Proctitis

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