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Anthrax Prophylaxis News

Anthrax Vaccine Shows Promise in Monkey Trial

Posted 1 Jul 2016 by Drugs.com

FRIDAY, July 1, 2016 – A vaccine made with a component of the bacteria that causes anthrax protected monkeys from the deadly infection in a preliminary trial. Previous research showed that this component – the anthrax capsule – played a pivotal role in providing protection, the researchers said. In this study, the same team of scientists at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) tested a higher dose of the anthrax capsule vaccine in monkeys exposed to lethal inhaled levels of anthrax spores. All the monkeys that received the vaccine survived, while the non-vaccinated monkeys died from anthrax, according to the study published online June 27 in the journal Vaccine. The results suggest that anthrax capsule is a highly effective vaccine ingredient and should be considered for use in future anthrax vaccines, the researchers said. Current anthrax ... Read more

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Inhalation Anthrax Treatment Anthim Approved

Posted 22 Mar 2016 by Drugs.com

MONDAY, March 21, 2016 – Anthim (obiltoxaximab) has been approved by the U.S. Food and Drug Administration to treat inhalational anthrax, a rare disease stemming from infected animal products. Bacillus anthracis spores also pose a deadly bioterrorism threat if released intentionally. Anthrax toxins can cause severe tissue damage and death, the FDA said Monday in a news release. Anthim, combined with certain antibacterial drugs, is designed to neutralize the toxins. The medication's effectiveness was evaluated in studies conducted on animals, since it wasn't ethical or feasible to conduct such trials with human volunteers, the agency said. The drug's safety was evaluated in 320 healthy human volunteers. The most common side effects included headache, itching, upper respiratory tract infection, cough, nasal congestion, hives and injection-site reactions including swelling, bruising and ... Read more

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FDA Approves Anthim (obiltoxaximab) for Inhalation Anthrax

Posted 22 Mar 2016 by Drugs.com

March 21, 2016 – On Friday, March 18, the U.S. Food and Drug Administration approved Anthim (obiltoxaximab) injection to treat inhalational anthrax in combination with appropriate antibacterial drugs. Anthim is also approved to prevent inhalational anthrax when alternative therapies are not available or not appropriate. Inhalational anthrax is a rare disease that can occur after exposure to infected animals or contaminated animal products, or as a result of an intentional release of anthrax spores. It is caused by breathing in the spores of the bacterium Bacillus anthracis. When inhaled, the anthrax bacteria replicate in the body and produce toxins that can cause massive and irreversible tissue injury and death. Anthrax is a potential bioterrorism threat because the spores are resistant to destruction and can be spread by release in the air. “As preparedness is a cornerstone of any b ... Read more

Related support groups: Anthrax, Anthrax Prophylaxis, Obiltoxaximab, Anthim

Anthrax Vaccine Approval Expanded

Posted 24 Nov 2015 by Drugs.com

TUESDAY, Nov. 24, 2015 – U.S. Food and Drug Administration approval for the BioThrax anthrax vaccine has been expanded to include adults aged 18 to 65 with known or suspected exposure, the agency said in a media release. The vaccine was first approved in 1970 for people at high risk of anthrax contact. Exposure to Bacillus anthracis bacteria, especially if inhaled, can cause death if not promptly treated. Anthrax is considered a potential bioterrorism weapon, since it is easy to disperse and is relatively hearty, the agency said. Exposure also is possible by contact with an infected animal or animal products. Expanded approval for the injected vaccine was granted under the agency's "animal rule," which states animals may be used to test a drug or product for purposes that aren't ethical or feasible among people, the FDA said. The BioThrax vaccine was tested on exposed rabbits and ... Read more

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FDA Approves BioThrax for Use After Known or Suspected Anthrax Exposure

Posted 23 Nov 2015 by Drugs.com

November 23, 2015 – The U.S. Food and Drug Administration today approved a new indication for BioThrax (Anthrax Vaccine Adsorbed) to prevent disease following suspected or confirmed exposure to Bacillus anthracis, the bacterium that causes anthrax disease. The vaccine’s new use is approved for people 18 through 65 years of age in conjunction with recommended antibiotic treatment. BioThrax was initially approved by the FDA in 1970 for the prevention of anthrax disease in persons at high risk of exposure. Anthrax disease, especially the inhalation form, is often fatal if not promptly treated. Anthrax is considered one of the more likely agents to be used in a biological attack, primarily because its spores are very stable and easy to disperse. Although it is rare, people may contract anthrax disease through natural exposures, such as contact with infected animals or contaminated animal p ... Read more

Related support groups: Anthrax Prophylaxis, Anthrax, Biothrax, Anthrax Vaccine Adsorbed

FDA Approves Raxibacumab to Treat Inhalational Anthrax

Posted 17 Dec 2012 by Drugs.com

December 14, 2012 – The U.S. Food and Drug Administration today approved raxibacumab injection to treat inhalational anthrax, a form of the infectious disease caused by breathing in the spores of the bacterium Bacillus anthracis. Raxibacumab also is approved to prevent inhalational anthrax when alternative therapies are not available or not appropriate. Raxibacumab is a monoclonal antibody that neutralizes toxins produced by B. anthracis that can cause massive and irreversible tissue injury and death. A monoclonal antibody is a protein that closely resembles a human antibody that identifies and neutralizes foreign material like bacteria and viruses. Anthrax is a potential biological terrorism threat because the spores are resistant to destruction and can be easily spread by release in the air. The FDA granted raxibacumab fast track designation, priority review, and orphan product ... Read more

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Anthrax Vaccine Shows Promise in Monkeys

Posted 22 Jan 2012 by Drugs.com

FRIDAY, Jan. 20 – Monkeys vaccinated with an anthrax capsule vaccine were protected against lethal anthrax infection, a new study has found. The anthrax capsule is a naturally occurring component of Bacillus anthracis, the bacterium that causes anthrax. This is the first successful use of a non-toxin vaccine to protect monkeys from anthrax, which is regarded as one of the most serious bioterrorism threats, according to the U.S. Army scientists who conducted the study. Bacillus anthracis produces three main components that enable it to cause harm – lethal toxin, edema toxin and the capsule. During anthrax infection, the capsule surrounds the bacterium and protects it from destruction by the body's white blood cells. In this study, the researchers found that the anthrax capsule vaccine induced anti-capsule antibody responses in both rabbits and monkeys. Vaccinated rabbits were not ... Read more

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Vaccinations Aren't Just for Kids

Posted 16 Sep 2011 by Drugs.com

FRIDAY, Sept. 16 – Public health experts often focus immunization awareness efforts toward protecting children, and with good reason: Facing a potentially bewildering schedule of vaccinations for their young ones, parents usually need all the help they can get. But vaccinations aren't just kid stuff. Medical science is creating an increasing number of immunizations targeted at adults, to help them avoid life-threatening diseases in middle-age and opportunistic infections when they're older. "Immunization is a life-long issue that we need to pay a lot of attention to," said Dr. Georges C. Benjamin, executive director of the American Public Health Association. Some adult vaccinations are very well-known, like the annual shot that aims to prevent the spread of influenza. "You need an influenza shot every year," Benjamin said. "Part of that is because the virus changes every year, ... Read more

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