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TNKase (Tenecteplase): A Better Clot-Buster Drug for Strokes?

Posted 26 Apr 2018 by Drugs.com

THURSDAY, April 26, 2018 – After a stroke, many patients are given the clot-busting intravenous drug alteplase, but another drug may be more effective, Australian researchers report. Among more than 200 stroke victims, TNKase (tenecteplase) was about twice as effective as alteplase in restoring blood flow to the brain, and it also resulted in less disability, the scientists found. "Tenecteplase ...

FDA Medwatch Alert: Activase (alteplase) 100mg by Genentech: Recall - Lack of Sterility Assurance

Posted 7 Sep 2017 by Drugs.com

ISSUE: Genentech is voluntarily recalling three lots of Activase (alteplase) 100mg vials, that were co-packaged with Sterile Water for Injection, to the hospital level. The vials of Sterile Water for Injection, manufactured by Hospira Inc., a Pfizer company, and packaged with Activase 100 mg, may be cracked or chipped at the neck of the vial and leaking.  See press release for affected lots. The ...

Are Stroke Centers Life Savers?

Posted 26 Jul 2016 by Drugs.com

TUESDAY, July 26, 2016 – The odds of surviving a stroke are slightly better for patients treated at hospitals with a specialized stroke department, known as primary stroke centers, a new study finds. But that benefit was only seen if stroke patients got to a stroke center in less than 90 minutes, the study authors said. "Treatment of stroke is very time sensitive. As the saying goes, time is ...

Clot-Busters Might Be Useful for 'Previously Dependent' Stroke Patients

Posted 22 Jan 2016 by Drugs.com

FRIDAY, Jan. 22, 2016 – Intravenous clot-busting treatment might benefit stroke patients who needed help with daily living before their stroke, a new study suggests. Stroke patients who already required daily living assistance are often left out of clinical trials of clot-busting treatment, the researchers said. With little information to go on, doctors might not treat these patients with ...

Extracting Clot Beats Clot-Busting Drug Alone in Study of Stroke Patients

Posted 3 Nov 2015 by Drugs.com

TUESDAY, Nov. 3, 2015 – Extracting a stroke-causing blood clot is better than just using a clot-busting drug for preserving brain function, a new analysis concludes. About 45 percent of patients who underwent the clot-removal procedure experienced functional independence at 90 days, compared with about 32 percent of patients treated with the clot-busting IV medication called tissue plasminogen ...

More Progress Needed To Get Stroke Patients Rapid Care

Posted 31 Jul 2015 by Drugs.com

FRIDAY, July 31, 2015 – Stroke victims still aren't getting treated soon enough, a new study suggests. Treating strokes quickly is critical, because the more time that elapses, the less effective stroke treatment may be, the researchers explained. A number of factors have reduced the time it takes stroke patients to get treatment. These include greater public awareness, better emergency dispatch ...

Many Hospitals Overestimate Their Adherence to Stroke Guidelines

Posted 22 Jul 2015 by Drugs.com

WEDNESDAY, July 22, 2015 – Many U.S. hospitals overestimate their ability to provide fast delivery of a clot-busting drug to stroke patients, a new study finds. The drug, called tissue plasminogen activator (tPA), has been shown to reduce the short- and long-term effects of stroke. It should be given to ischemic stroke patients within 60 minutes of their arrival at the hospital, according to ...

Wide Variations Seen in U.S. Stroke Care

Posted 7 Jul 2015 by Drugs.com

TUESDAY, July 7, 2015 – Americans' odds of receiving a drug that can halt strokes in progress may vary widely depending on their ZIP codes, a new study finds. Experts said the findings, reported in the July issue of the journal Stroke, help verify what everyone has suspected: There are disparities in emergency stroke care across the United States, specifically in the use of a clot-busting drug ...

Expert Tips to Detect Early Warning Signs of Stroke

Posted 11 May 2015 by Drugs.com

SUNDAY, May 10, 2015 – Prompt treatment of stroke is key to preventing death and disability, but not everyone knows how to quickly identify the early warning signs of stroke. "Today, thanks to early detection, aggressive treatment and new intervention therapies, more stroke patients than ever are returning to normal life with limited to no disability," said Dr. Stanley Tuhrim, director of the ...

Clot-Busting Drug May Be Safe for Those With 'Wake-Up' Strokes

Posted 12 Feb 2015 by Drugs.com

THURSDAY, Feb. 12, 2015 – The clot-busting drug known as tPA appears safe for those who wake up in the morning to find they've had a stroke, a small new study suggests. Many people with these "wake-up strokes" do not receive tPA (tissue plasminogen activator) because of restrictions on its use to within three hours of the start of stroke symptoms. That's because for most patients who realize ...

More Stroke Patients Getting Clot-Buster Quickly, Study Shows

Posted 11 Feb 2015 by Drugs.com

WEDNESDAY, Feb. 11, 2015 – More community hospitals are giving a powerful clot-busting medication to stroke victims, improving their chances of survival and recovery, new research shows. These local hospitals are becoming more comfortable using the clot-busting drug tPA (tissue-plasminogen activator) due to a new treatment scheme known as "drip and ship," said study author Dr. Kevin Sheth, chief ...

Special Ambulance Delivers Vital Stroke Care More Quickly

Posted 21 Nov 2014 by Drugs.com

FRIDAY, Nov. 21, 2014 – Stroke outcomes are better when patients are treated in an ambulance by a neurologist equipped with a CT scanner and clot-busting drugs, German researchers report. The sooner patients get the clot dissolver – tissue plasminogen activator (tPA) – the better the outcome after a stroke, the researchers noted. For the best outcome, the drug needs to be given within the ...

Speedy Delivery of Clot-Busting Drug Helps Stroke Patients Avoid Disability

Posted 6 Aug 2014 by Drugs.com

WEDNESDAY, Aug. 6, 2014 Another study confirms that "time is brain" when treating stroke patients with a powerful clot-busting drug, tPA. Prompt treatment with tissue plasminogen activator (tPA, also known as alteplase) "is a very effective means of limiting the degree of disability in stroke patients," study co-author Dr. Jonathan Emberson, of University of Oxford in the U.K., said in a news ...

Pros, Cons to Dissolving Lung Clots: Study

Posted 17 Jun 2014 by Drugs.com

TUESDAY, June 17, 2014 – Drugs used to break up blood clots in the lungs may lower the risk of death, but they also increase the risk of bleeding, a new study finds. Researchers analyzed data from 16 trials involving use of clot-busting drugs called thrombolytics to treat life-threatening clots in the lungs (pulmonary embolism). Despite the drugs' apparent life-saving benefits, the risk of major ...

Ultra-Early Treatment Reduces Disability After Stroke: Study

Posted 22 Aug 2013 by Drugs.com

THURSDAY, Aug. 22 – People suffering mild to moderate ischemic strokes who get immediate medical treatment can greatly reduce their odds of disability, a new study suggests. An ischemic stroke occurs when a clot blocks blood flow to the brain. According to the American Stroke Association, nearly nine out of every 10 strokes are ischemic strokes. Current guidelines recommend giving a ...

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Myocardial Infarction, Heart Attack, Ischemic Stroke, Pulmonary Embolism, Thrombotic / Thromboembolic Disorder

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