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Could Common Heartburn Drugs Up Stroke Risk?

Posted 15 Nov 2016 by Drugs.com

TUESDAY, Nov. 15, 2016 – A popular category of heartburn medications – including Nexium, Prevacid, Prilosec and Protonix – may increase your risk of stroke, a new study suggests. Known as proton pump inhibitors (PPIs), these drugs increased people's overall stroke risk by 21 percent, said study lead author Dr. Thomas Sehested. However, the risk appears to be driven by people who take high doses, added Sehested, research director at the Danish Heart Foundation in Copenhagen. "People treated with a low dose of PPIs did not have a high risk of stroke," he said. "Those treated with the highest doses of PPIs had the highest risk of stroke." The extent of risk also depends on the specific PPI taken. At the highest dose, stroke risk ranged from 30 percent for lansoprazole (Prevacid) to 94 percent for pantoprazole (Protonix), the researchers said. Takeda Pharmaceutical, the maker of ... Read more

Related support groups: GERD, Heart Disease, Ischemic Stroke, Omeprazole, Nexium, Dementia, Prilosec, Zantac, Protonix, Indigestion, Alzheimer's Disease, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Transient Ischemic Attack, Pepcid, Barrett's Esophagus, Aciphex

Health Tip: Is it Indigestion?

Posted 6 Jun 2016 by Drugs.com

-- If you've eaten too much or indulged in a food that's greasy, fatty or spicy, you may have an uncomfortable feeling known as indigestion. Here are common symptoms, courtesy of the Cleveland Clinic: A burning sensation in the stomach or upper abdomen. An acidic taste in the mouth. Pain in the abdomen. Occasional diarrhea. Bloatedness or gassiness. Vomiting or nausea. Growling stomach. Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Zantac, Protonix, Indigestion, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Tums, Milk of Magnesia, Aciphex, Caltrate, Famotidine, Duodenitis/Gastritis, Heartburn Relief

Clues to How Popular Heartburn Drug Might Harm Arteries

Posted 10 May 2016 by Drugs.com

TUESDAY, May 10, 2016 – A popular over-the-counter heartburn medication accelerated aging of blood vessel cells in lab tests, raising red flags about its long-term effect on heart health, researchers say. Faster aging of blood vessel cells exposed to the antacid Nexium (esomeprazole) might potentially hinder the tasks these cells perform to prevent heart attack and stroke, the new study suggests. These lab results could explain why other studies have shown increased risk of heart disease in people who use proton pump inhibitors (PPIs) – the class of heartburn medication that includes Nexium, said study senior author Dr. John Cooke. "Our finding that the lining of blood vessels is impaired by proton pump inhibitors is a unifying mechanism for the reports that PPI users are at increased risk for heart attack, stroke and renal failure," said Cooke, chair of cardiovascular sciences at the ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Indigestion, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Tums, Milk of Magnesia, Aciphex, Caltrate, Duodenitis/Gastritis, Rabeprazole, Calcium Carbonate, Zegerid, Esomeprazole, Prevention of Cardiovascular Disease

1 in 4 Hospitalized Newborns Gets Heartburn Drugs, Despite Risks

Posted 27 Apr 2016 by Drugs.com

WEDNESDAY, April 27, 2016 – Despite reported risks, nearly one in four infants in neonatal intensive care units (NICUs) are given stomach acid-suppressing drugs, researchers report. However, they noted that the use of these medications has started to decline some in recent years. A number of studies have linked the use of stomach acid-suppressing drugs in hospitalized high-risk infants with infections, necrotizing enterocolitis (a serious disease where intestinal tissue begins to die off) and increased risk of death, the researchers said. These drugs include histamine-2 receptor antagonists such as ranitidine (Zantac), and proton pump inhibitors such as esomeprazole (Nexium). Researchers at Nationwide Children's Hospital in Columbus, Ohio, analyzed data from 43 children's hospitals across the United States from 2006 to 2013. They found that nearly 24 percent of roughly 122,000 newborns ... Read more

Related support groups: Omeprazole, Nexium, Prilosec, Zantac, Protonix, Pantoprazole, Ranitidine, Lansoprazole, Dexilant, Prevacid, Pepcid, Delivery, Aciphex, Famotidine, Heartburn Relief, Rabeprazole, Zegerid, Esomeprazole, Zantac 150, Vimovo

Widely Used Heartburn Drugs Linked to Dementia Risk in Study

Posted 15 Feb 2016 by Drugs.com

MONDAY, Feb. 15, 2016 – A popular class of heartburn medications might raise a senior's risk of dementia, a new study suggests. Called proton pump inhibitors (PPIs), this group of drugs includes Prilosec, Nexium and Prevacid. They work by lowering the amount of acid produced by the stomach. But German researchers found that people 75 or older who regularly take the medications had a 44 percent increased risk of dementia, compared with seniors not using the drugs. The study only found an association, however, and not a cause-and-effect link. "To evaluate cause-and-effect relationships between long-term PPI use and possible effects on cognition in the elderly, randomized, prospective clinical trials are needed," said corresponding author Britta Haenisch, from the German Center for Neurodegenerative Diseases in Bonn. In the meantime, "Clinicians should follow guidelines for PPI ... Read more

Related support groups: GERD, Gas, Omeprazole, Nexium, Dementia, Prilosec, Protonix, Indigestion, Alzheimer's Disease, Pantoprazole, Stomach Ulcer, Lansoprazole, Dexilant, Prevacid, Gastric Ulcer, Aciphex, Peptic Ulcer, Duodenitis/Gastritis, Prevpac, Mild Cognitive Impairment

Heartburn Meds Linked to Chronic Kidney Disease

Posted 11 Jan 2016 by Drugs.com

MONDAY, Jan. 11, 2016 – A type of heartburn medication called proton pump inhibitors may be linked to long-term kidney damage, a new study suggests. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers, said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore. The study was published Jan. 11 in JAMA Internal Medicine. The study doesn't establish a direct cause-and-effect relationship between the drugs and chronic kidney disease. However, Grams said, "We found there was an increasing risk associated with an increasing dose. That suggests that perhaps this observed effect is real." Proton pump ... Read more

Related support groups: GERD, Omeprazole, Nexium, Prilosec, Protonix, Renal Failure, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Aciphex, Chronic Kidney Disease, Rabeprazole, Zegerid, Esomeprazole, Prilosec OTC, Dexlansoprazole, Prevacid SoluTab, Kapidex, Zegerid OTC

Chronic Heartburn Drugs Tied to Higher Risk of Kidney Disease

Posted 27 Oct 2015 by Drugs.com

TUESDAY, Oct. 27, 2015 – A common type of heartburn medication called proton pump inhibitors (PPIs) seem to be linked with increased risk of chronic kidney disease, two new studies suggest. Prilosec, Nexium and Prevacid belong to this class of drugs, which treat heartburn and acid reflux by lowering the amount of acid produced by the stomach. While the current studies have shown an association between these drugs and the development of chronic kidney disease, they did not prove a cause-and-effect relationship. Still, the lead author of one of the studies believes, "It is very reasonable to assume that PPIs themselves can cause chronic kidney disease," said Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, N.Y. "Patients should only use PPIs for [U.S. Food and Drug Administration]-approved indications, and ... Read more

Related support groups: High Blood Pressure, Diabetes, Type 2, GERD, Hypertension, Omeprazole, Nexium, Prilosec, Protonix, Renal Failure, Indigestion, Pantoprazole, Lansoprazole, Dexilant, Prevacid, Aciphex, Chronic Kidney Disease, Duodenitis/Gastritis, Rabeprazole, Zegerid, Esomeprazole

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