I've been on xyrem since December. I normally have seasonal depression but by April is usually subsides. Im wondering if the depression i have now is due to the medication. Im highly cynical and feel like i can't even trust my own thoughts.
Taralough. Depending on where you are the seasonal depression is way off this year. But this medication can also increase depression as you start on it or take a break but if you have been on it since dec this last year I would call your doctor and let them know that the depression is much worse. You might want to read some of this that I copied off of drug.com and if in dought, by all means, call the doctor. And hope it lifts pretty fast But I was just reading something like with people with you and my condition in most areas it is extended by a month or two either way due to this crazy weather. Would love to hear what your doctor says if you have to call them. BUT this was mostly the stuff during the trial. good luck and feel free to check back with us to anytime. Chuck1957 drug info.((Important Administration Instructions
Take the first dose of Xyrem at least 2 hours after eating because food significantly reduces the bioavailability of sodium oxybate.
Prepare both doses of Xyrem prior to bedtime. Prior to ingestion, each dose of Xyrem should be diluted with the approximately ¼ cup (approximately 60 mL) of water in the empty pharmacy vials provided. Patients should take both doses of Xyrem while in bed and lie down immediately after dosing as Xyrem may cause them to fall asleep abruptly without first feeling drowsy. Patients will often fall asleep within 5 minutes of taking Xyrem, and will usually fall asleep within 15 minutes, though the time it takes any individual patient to fall asleep may vary from night to night. Patients should remain in bed following ingestion of the first and second doses, and should not take the second dose until 2.5 to 4 hours after the first dose. Patients may need to set an alarm to awaken for the second dose. Rarely, patients may take up to 2 hours to fall asleep.
Dose Modification in Patients with Hepatic Impairment
The recommended starting dose in patients with hepatic impairment is 2.25 g per night administered orally in two equal, divided doses: approximately 1.13 g at bedtime and approximately 1.13 g taken 2.5 to 4 hours later [see Use in Specific Populations (8.6); Clinical Pharmacology (12.3)].
Dose Adjustment with Co-administration of Divalproex Sodium
- Xyrem Information for Consumers
- Xyrem Information for Healthcare Professionals (includes dosage details)
- Side Effects of Xyrem (detailed)
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