... got back into a pain management clinic. This time with good results. I'm taking Morphine Sulfate 30 mg ER, 1 every 8 hours, and Oxycodone 15 mg up to 4 times a day for breakthrough pain. I've never had anxiety issues until recently, I would say the last 2 weeks I was taking Morphine Sulfate 15 mg ER. Not sure of the cause but, I did read a little about it. Has this happened to anybody else because of medicine? Have you tried natural remedies to help?