I currently take 75mg of immediate release effexor. I have a hard time swallowing pills so that was all I could take. I split the dose in half and take half in the morning and half in the evening. I took it all at once in the morning and didnt notice much difference. I am suffering from horrible flu-like-symptoms (very achy) and could it be that I am not taking enough or its just not working properly? Is the half life too quick and I dont have a steady amount in my system? Not sure. I really dont want to up the does and have it not work and have to get off it because I heard it is a hard.