It took two weeks to fully kick in, but I am experiencing a dramatic decrease in appetite and cravings. Have to remind myself to eat. I lost 25 pounds several months ago, but then got stuck at 233 pounds and could not get below that. So this is encouraging. Am using the Scale Down scale and My Fitness Pal and carefully tracking of everything I eat and drink. I have also been in a better mood than usual, which is good, because I suffer from anxiety. I have had no noticeable side effects from Contrave. No pill or surgery is a "magic bullet." It takes a lot of determination, self education about nutrition and health, more exercise and keeping a positive attitude. Have had tremendous support from husband, family and friends. Support can make a huge difference in weight loss success. Anyone else have positive results while taking Contrave?