... elimination ?
"... Pharmacokinetics: Succinylcholine is poorly absorbed from the gastrointestinal tract, but when administered intravenously, it has a rapid onset and a short duration of action. Following IV administration of 10—30 mg to healthy adults, complete muscle relaxation occurs in 0.5—1 minute. This effect persists for 2—3 minutes and gradually dissipates within 10 minutes. After IM injection, muscle relaxation occurs in 2—3 minutes and persists for 10—30 minutes. Patients with low pseudocholinesterase concentrations may experience longer durations of action.
After IV administration, succinylcholine is distributed in the extracellular fluid and rapidly reaches its site of action at the motor endplate of the myoneural junction. Following an intravenous bolus dose of 1 or 2 mg/kg, succinylcholine serum concentrations are below the detection limit (<2 ug/mL) after 2.5 minutes. Because it is highly ionized and has low fat solubility, succinylcholine does not readily cross the placenta.
Up to 10% of a succinylcholine dose is excreted unchanged in the urine. The remainder of a dose is rapidly hydrolyzed by plasma pseudocholinesterase to succinlymonocholine and choline. Succinylmonocholine possesses nondepolarizing muscle-relaxant properties. Succinylmonocholine is excreted partly in urine; the remainder is broken down by alkaline hydrolysis to the inactive metabolites succinate and choline. Hydrolysis of succinylmonocholine occurs relatively slowly, so succinylmonocholine can accumulate and cause prolonged apnea, especially in patients with impaired renal function."
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