I have been on metformin (500mg once a day) going on 3 years for PCOS. I forgot to get my prescription refilled and I haven't taken metformin for 5 days. I noticed last night very blotchy skin and a few breakouts on my face..nothing like I've had since I started metformin. Is this a normal symptom for being off of the medicine for 5 days? Also, would it be worth asking my doctor to up my dosage? I have experience weight gain and still have unwanted facial hair. Any advice will help!