This is pretty weird. I was on Prempro for years due to severe aura and HFs. The cost of Prempro has skyrocketed over the last three years so I switched to estradiol/medroxyprogesterone. I've been on duloxetine (Cymbalta) for neuropathy during this entire time. The estradiol/medroxyprogesterone did nothing to help the aura and hot flashes and almost seemed to make it worse. I did a sudden cessation of estradiol/medroxyp and guess what? My HFs and auras are less frequent and much less severe. What's going on? Anyone else experience this?