So its been 8 weeks since i started the zoloft, i am at 150mg, i do notice a change for the better, but still having some symptoms of depression. It did not help that during the transition from prystiq to zoloft i forgot to take my BCP, and put my cycle all out of wak. I want to think positive and know that it takes time but i cant help but think that its been 2 1/2 months and 2 different antidepresaants and here i am still with symptoms. I have my first appointment with a psychiatrist next week, im hoping she can help.