I am a 52 year old female with MDD long term. I also have chronic pain and neuropathy problems. I have Fibromyalgia and I get a lot of migraines. I also have a lot of symptoms of Sojourner's Syndrome. I use a Fentanyl pain patch and worry that these two drugs will not mix well, but my doctor isn't concerned. I've tried several antidepressants including Prozac, Cymbalta, Lexapro, Celexa, Effexor, etc. All of them caused severe stomach pain, so I couldn't continue taking them. My doctor said that even if I have issues with this medication, that I need to stay on it and give it a chance to work and for the side effects to diminish over time. I'm scared to take it. Please tell me if this is really worth trying and if the side effects lessened over time for you. I'm so depressed and Wellbutrin just isn't working like it used to. It was the only drug I didn't get sick from. Just my luck.