I suffer from PTSD and anxiety. My doctor is tapering me on seroquel (which works for me, but causes weight gain), at the same time as beginning this week with 25mg zoloft. I have problems sleeping, my anxiety has worsened greatly, I'm unmotivated, and I'm feeling on the verge of a panic attack. From what I'm reading, this seems to be normal. But due to my history of occasional seizures, I don't want to risk it. It seems that the benefit does NOT outweigh the side effects. Correct me if I'm wrong, but I'm ready to start a "down with Zoloft!" campaign.