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I started talking Deplin and felt fantastic. Now I am tired. Can you develop a tolerance?

Responses (2)

Sp111 23 Jun 2013

Just wonderIng how you are feeling on the deplin. I just started today. I take trazadone also

anniepc1234 25 Jun 2013

I have been taking Deplin for over a year along with my antidepressant. I know of no reason why you would get a tolerance with Deplin. It is a water-soluble mega-vitamin and in these higher doses it helps out the antidepressant do its work on the brain. It's not addictive, so maybe you should look at other possible causes for your fatigue. Have your doc run some lab work.

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