Ive been reading reviews and info about it and im worried. I take tizanidine (for muscle spasms from my migraines) as well and read its on the drug interaction list and should definitely not be taken with cryselle, yet my doctor prescribed both at the same time. So im wondering if its safe at all, if my bc is low dosage. Also, ive noticed cryselle recommends taking the pill after dinner but my doctor said in the morning was best so i take it at 730 am everyday. Does that effect the effectiveness at all? Thanks.