... with Lexapro. Basically it caused me to have a panic attack that ended in the Emergency Room. My heart rate and BP was sky high for hours. I also tried a small dose of Zoloft two years ago and it made me jittery and anxious as well so I stopped. I have heard the start up affects of Paxil are smoother. Can anyone who has been on multiple SSRIs comment on Paxil start up affects? I literally get anxiety just THINKING about taking the Paxil but I know I need to because my life is spiraling downhill very fast. Thank you so much!