I'm on Seroquel twice daily (100mg in morning 450mg at night) and also 25mg x 2 P.R.N.

Initially I was prescribed XR as well but have since been taken off, as opposed to just throwing the tablets away, can I split them and use them split instead of the 25mg I take P.R.N?

AFAIK the coating is what helps the slow release? unless I'm mistaken.