Spironolactone is a diuretic, which is commonly referred to as a "water pill." It is known as an aldosterone antagonist, which means that it blocks aldosterone receptors. Aldosterone is a hormone that causes the body to retain water. By blocking it, spironolactone increases the amount of salt and water the kidneys remove from the blood. This extra salt and water is passed out through urine. By increasing the amount of water removed from the blood, spironolactone causes a decrease in blood volume. Because of this effect, the medication can lower blood pressure and also help with water retention.
Spironolactone is a "potassium-sparing" diuretic, which means that it does not cause low potassium levels in the blood, like many other diuretics. In fact, this medication usually increases potassium levels, an effect that can be used to treat low potassium levels (hypokalemia).
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- Spironolactone Information for Consumers
- Spironolactone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Spironolactone (detailed)
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