I read that this medicine causes rumors? I am worried to take it.
In lab rodents, but it is unknown currently whether or not there is an association in humans. The issue was first raised back in 75 when a case report came out about 5 women who devolped breast tumors, however they were on a few different meds so it is unknown if it was medication induced. This did lead to the black box warning by the manufacturer. There have been a few other studies to determine if there is an increased risk forbreast tumors in those using spironolactone, so far no increased risk.
Shaw JC, White LE. Long-term safety of spironolacone in acne: results of an 8 year follow-up study. J Cut Med and Surg. 2002;12:541–545.
Danielson DAN, Jick H, Hunter JR, et al. Nonestrogenic drugs and breast cancer. Am J Epidemiol. 1982;116:329–332.
Brest AN. Spironolactone in the treatment of hypertension: a review. Clin Ther. 1986;8:585–586.
Loube SD, Quirk RA. Breast cancer associated with administration of sprionolactone [Letter] Lancet. 1975;1:1428–1429.
Shaw JC. Spironolactone in dermatologic therapy. J Am Acad Dermatol. 1991;24:236–243.
- Spironolactone Information for Consumers
- Spironolactone Information for Healthcare Professionals (includes dosage details)
- Side Effects of Spironolactone (detailed)
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