(I have tried everything under the sun, including Accutane several times, and nothing compares to Spiro). However, recently my kidney function came back low. My doctor told me to stop taking Spiro for a month, get more blood work done, and then we would take treatment from there. It's been three weeks and my acne is back with a vengeance! If I can't get back on Spiro, any suggestions for successful treatment of hormonal acne? Please help!