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Does spironolactone have any effect on the PSA?

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Inactive 5 Dec 2012

Hello Manabouttown13,

Spironolactone belongs to the drug classes aldosterone receptor antagonists, potassium-sparing diuretics.

Having said that is not in the drug class, nor the type of medication to increase the PSA (Prostate-specific antigen) levels.

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Normally, only small amounts of PSA leak into the blood. Increased levels of PSA may indicate a problem within the prostate. Prostate cancer, the formation of a tumor due to the abnormal growth of cells in the prostate, causes PSA levels to rise. In general, doctors consider PSA levels of 4 nanograms/milliliter of blood as high, prompting them to perform additional testing on the prostate, according to MedlinePlus, a service of the National Institutes of Health. However, a high PSA number could be triggered by unrelated factors such as medications.

Doctors use cyclophosphamide, a chemotherapeutic agent, to treat many types of cancers including lymphoma, leukemia, multiple myeloma, neuroblastoma and retinoblastoma, according to the American Cancer Association. As an alkylating agent, cyclophosphamide targets rapidly dividing cells and damages the DNA in order to kill the cells. cyclophosphamide can also affect normal cells, resulting in numerous side effects. Lab Tests Online reports cyclophosphamide as one medication that can affect PSA readings, causing them to be too low or too high.

Methotrexate, classified as an antimetabolite medication, slows the growth of cells. Doctors therefore prescribe it to treat conditions including psoriasis, rheumatoid arthritis and some forms of cancer. Methotrexate can act upon other cells within the body. Although the mechanism may remain unclear, methotrexate can affect PSA levels, resulting in high or low numbers, according to Lab Tests Online.

PSA Rising: Prostate
MedLine Plus: PSA
Lab Tests Online: PSA Test
American Cancer Association: Cyclophosphamide


Thiazide diuretics have been found to lower PSA levels. These are prescription-only medications typically used to treat high blood pressure as well as increase urine output and reduce the total amount of water in the body, according to A study published in the Journal of Clinical Oncology found that men who took these diuretics over five years had a 25 percent reduction in PSA levels, and men taking both statin drugs and thiazide diuretics had a 36 percent reduction in PSA levels.

Statin drugs, or statins, can also lower PSA levels. According to a study in the Journal of Clinical Oncology, men taking statin drugs over five years experienced a 13 percent reduction in PSA levels--and even more of a reduction when also taking thiazide diuretics. Statins are typically prescribed to help lower cholesterol levels, says the University of California-San Diego.

Studies are mixed regarding vitamin E and PSA levels. According to the University of Maryland Medical Center, some studies have found that men taking high doses of vitamin E had lower risks of developing prostate cancer, while others found an increase in risk when high doses were consumed.

References: Diuretics, thiazide
American Society of Clinical Oncology: "Journal of Clinical Oncology": Impact of common medications on serum total prostate-specific antigen levels: Analysis of the National Health and Nutrition Examination Survey
University of California-San Diego Statin Effects Study: Statin information
University of California-San Diego Statin Effects Study: Statin adverse effects
University of Maryland Medical Center: Vitamin E
National Cancer Institute: Prostate-Specific Antigen test

Your question, I must say educated me, thank you, for I value knowledge.

God bless,

Inactive 5 Dec 2012
MacIntosh12 5 Dec 2012

Now, THIS answer goes beyond the call of duty, it goes the extra ten miles!
Nice job, my friend! Impressive indeed!

Inactive 5 Dec 2012

Many thanks L for your kind words.- free discount card

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