My daughter who is only 12 has been dealing with acne for about 18 months. She is under the care of a dermatologist and we have tried all kinds of topics along with trying doxycyline, minocycline, and bactrim. the most improvement came with bactrim but still not cleared. we are now starting Spiro, wondering if anyone has had positive results on a girl of this age, who has not yet started her period, but has begun puberty.