... receptor site. Trazodone and nefazodone only affect the reuptake of serontonin at one receptor..while SSRis and SSNRis affect the reuptake at two receptor sites..I have taken trazodone..still take 50mg at bedtime..and nefazodone for years..with good results..well nothing lasts forever..Doc switched me to Effexor..which kind of sort of is the best psych med I have ever taken... makes me feel better and feel bad all at the same time..kicking in at that dirty receptor as well as the good one... wonder what others take for social anxiety