With or without food? I've never "noticed" much relief from the spasms on Sleelaxin. I used to take Soma and they REALLY worked but no doctor anywhere near here will write those ESP. W/long term narcotic pain relievers. What has been y'alls experience with Zanaflex? I also started Opana 15 mg SR(?)the extended or slow release) every 12 hours, is it best to take it without food 2hours before and after to get the correct effect? Thanks anybody for ANY HELP???