... the nose, head down position. No improvement so far. I saw an article in Medscape, "Drug Delivery to the Nasal Sinuses," (1/27/14) stating, in part, "When delivery devices were analyzed, large volume (>50mL) irrigations showed improved penetration into the paranasal sinuses ... Low volume devices, including sprays, drops and nebulizers, failed to reliably penetrate and distribute into the paranasal sinuses , regardless of the patient's surgical state." Can someone amplify this for me, especially in regard to what device is considered "high volume." Neilson Jacobs