I have been on simponi for about a year and half now! I was started on the medication after I had a blood transfusion caused by being anemic. I have also seen that getting anemic is a side affect! But I started the medication for my arthritis problem. The medication work very well with that I get not much pain. But I have noticed I am getting ill once a month some months is worse than others. I am not sure if i should stop taking because of the infections, cancer or any other problems I can get from taking this medication.