Would like to get some opinions on phenobarbital and Keppra taken together should there be any dangerous side effects. Been on Dilantin and phenobarbital for 40 years and after having partial seizures for the first time few months ago my new neurologist gave me a new prescription, Keppra, in lieu of Dilantin. ... wondering how this works with phenobarbital? I know and understand everyone differs but it's good to hear some experiences from other people who have taken such medicines for epilepsy. Thanks.