my wife (age 79) has been taking the above medicines for years. her blood pressure became 180mmhg or more while lying down, 140 or less while sitting and 90 - 73 while standing. please tell me whether it could be the side effects of hyzaar and/or tekturna both. thank you very much for your guidance and help. kc fu
With regards to the added comment, the only person qualified to make those changes is her Doctor, for her own personal safety.-
Side effects of Hyzaar
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
In rare cases, hydrochlorothiazide and losartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine.
Stop using this medication and call your doctor at once if you have a serious side effect such as:
feeling light-headed, fainting;
swelling, rapid weight gain;
fast or pounding heartbeats;
urinating more or less than usual, or not at all;
jaundice (yellowing of the skin or eyes); or
dry mouth, increased thirst, drowsiness, restless feeling, confusion, increased urination, fast heart rate, fainting, or seizure (convulsions).
Less serious side effects may include:
runny or stuffy nose, sore throat; or
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any of these serious side effects:
feeling light-headed, fainting;
nausea with slow uneven heart rate and a weak pulse; or
swelling around your eyes.
Less serious side effects may be more likely to occur, such as:
stomach pain or upset, diarrhea, heartburn;
itching or skin rash;
headache, dizziness, tired feeling;
back pain, joint pain or swelling; or
stuffy nose, sore throat, cough.
Theses are not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.
Interactions between both medications are also very important.-
No interactions where found with regards to the medications, but with food tes.-
Interactions between your selected drugs and food
losartan ↔ food
Applies to: Hyzaar (hydrochlorothiazide/losartan)
GENERALLY AVOID: Moderate-to-high dietary intake of potassium, especially salt substitutes, may increase the risk of hyperkalemia in some patients who are using angiotensin II receptor blockers (ARBs). ARBs can promote hyperkalemia through inhibition of angiotensin II-induced aldosterone secretion. Patients with diabetes, heart failure, dehydration, or renal insufficiency have a greater risk of developing hyperkalemia.
MANAGEMENT: Patients should receive dietary counseling and be advised to not use potassium-containing salt substitutes or over-the-counter potassium supplements without consulting their physician. If salt substitutes are used concurrently, regular monitoring of serum potassium levels is recommended. Patients should also be advised to seek medical attention if they experience symptoms of hyperkalemia such as weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs.
MONITOR: Grapefruit juice may modestly decrease and delay the conversion of losartan to its active metabolite, E3174. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruits. The clinical significance is unknown. Moreover, pharmacokinetic alterations associated with interactions involving grapefruit juice are often subject to a high degree of interpatient variability.
MANAGEMENT: Patients who regularly consume grapefruits and grapefruit juice should be monitored for altered efficacy of losartan. Grapefruits and grapefruit juice should be avoided if an interaction is suspected. Orange juice is not expected to interact.
aliskiren ↔ food
Applies to: Tekturna (aliskiren)
MONITOR: High-fat meals can substantially reduce the absorption of aliskiren. According to the product labeling, administration with a high-fat meal decreased the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of aliskiren by 85% and 71%, respectively. In clinical trials, aliskiren was administered without a fixed requirement in relation to meals.
MANAGEMENT: To ensure steady systemic drug levels and therapeutic effects, patients should establish a routine pattern for administration of aliskiren with regard to meals.
Take care and have a nice day.
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