I have tried cymbalta and took it during dinner I was fine until the next morning as I felt like I got hit in the back of the head with a sledge hammer and was not myself that whole day... It was the first day I tried it when I called the doctor he just told me not to take it... I have generalized depression and some anxiety and this was suppose to treat this. My own doctor prescribed me paxil 5 miligrams a day and am very skeptical to use it she is a nurse practitioner that took over for my family physician that at one time said she would not put me on an anxiety medication... that was over 10 years ago... I have a lot of physical problems as well and due to this I am unable to work and has caused the depression to worsen...