I have a friend on Nplate, with ITP. He suffered tremors, convulsions and had to be hospitalized. He is now heavily sedated and in the hospital over 3 weeks. During this time he continues to get his Nplate treatments once per week in spite of a severe reaction each time. I just know that he hated the treatments and dreaded them. He had a treatment the day before he was hospitalized. Does anyone know of anyone else with a severe reaction such as this? It may be a very good drug for some but for him it seems not so good.