I am taking Zyclara (Imiquimod cream) 3.75% one week on, one week off, one week on, then one week off. I am taking it for precancer spots on my face. I just finished my first week, my face was really red in spots and sore, but today it is feeling better, still looks red, bumpy and a bit flaky. I have had a few reactions to the cream, day two I felt like I had the flu, day 4 & 5 my armpits were prickly. Yesterday and today are my worst days, my lower back is in a lot of pain. I am not sure if this can be related to the medication. I have taken tylenol and Aleve today and have had no relief. On a scale from 1 - 10 the pain is an 8. Is this common, has anyone experienced this?