Yes. 50 mg is considered a starting therapeutic dosage for sertraline. While 25 mg of Trazodone is not considered a therapeutic dosage for depression but is usually prescribed in that amount (or more) as a sleep aid. You would have to take a lot more of both to be at risk of Serotonin Syndrome.
Yes, but I would suggest taking the trazodone at bedtime because drowsiness is a very common side effect.
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