... schizoaffect disorder. They have him on Respirdal, vistril, zoloft and klonopin. He isn't sleeping at night, he kicks and can't keep still and his moods are still down. How long does it take on the medication before he should see some improvement? I was looking at a few of the other atypical anti-psychotic drugs that others take that have much better results. I don't want him to keep taking this drug regimen if it isn't working for him. The longer it takes gives him time to create reasons to be down and feel like he is never going to be right again. Thank you A worried Wife