I take 10mg before bed. I also started taking Lovox, I believe. Also, adivan as needed. It's only been about a week and I can see a huge improvement. I assume it's not the Lovx, as it takes longer to build in the system or something. My biggest complaints were no sleep and obsessive thoughts. I've been able to get 5 or more solid hours of sleep every night. The thoughts have slowed quite a bit. The first medication I have ever felt or seen a difference on. Only downside is I have already gained a few pounds. Which is ok now, but if it just continues eventually it could be more harmful than good. I eat fairly healthy so it's not my immediate concern. Advice on up,lower, keep dose