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Is it safe to take metronidazole together with amoxycillin?

Responses (1)

masso 7 Nov 2017

Interactions between your selected drugs
No results found - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Other drugs and diseases that your selected drugs interact with
amoxicillin interacts with more than 30 other drugs and 6 diseases.
metronidazole interacts with more than 200 other drugs and 7 diseases.

Interactions between your selected drugs and food
Major
metronidazole food
Applies to: metronidazole
Consumer information for this interaction is not currently available.

CONTRAINDICATED: Use of alcohol or products containing alcohol during nitroimidazole therapy may result in a disulfiram-like reaction in some patients. There have been a few case reports involving metronidazole, although data overall are not convincing. The presumed mechanism is inhibition of aldehyde dehydrogenase (ALDH) by metronidazole in a manner similar to disulfiram. Following ingestion of alcohol, inhibition of ALDH results in increased concentrations of acetaldehyde, the accumulation of which can produce an unpleasant physiologic response referred to as the 'disulfiram reaction'. Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion. Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmia, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death. However, some investigators have questioned the disulfiram-like properties of metronidazole. One study found neither elevations in blood acetaldehyde nor objective or subjective signs of a disulfiram-like reaction to ethanol in six subjects treated with metronidazole (200 mg three times a day for 5 days) compared to six subjects who received placebo.

MANAGEMENT: Because clear evidence is lacking concerning the safety of ethanol use during nitroimidazole therapy, patients should be apprised of the potential for interaction. Consumption of alcoholic beverages and products containing propylene glycol is specifically contraindicated during and for at least 3 days after completion of metronidazole and benznidazole therapy according to their product labeling.

Therapeutic duplication warnings
No therapeutic duplications were found for your selected drugs.

https://www.drugs.com/interactions-check.php?drug_list=187-0,1617-0

Regards, masso.-

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