But gradually lost its effectiveness. I noticed that it began spreading eventually to nearly all parts of my body. In the end of taking Requip it was working maybe 15% of the time. I had also to take sleep meds for my insomnia. I had a set time (2 hours), i had to wait on the Requip before I could take my sleep meds to work. I've now been on Mirapex with no more RLS successfully for about a year and a half,among some side effects from it. I still wait 2 hours after Mirapex before I take my sleep meds (serequel & diphenhydramine)... Does anyone else have to wait or have any similar situation??