... I currently take 20mg Embrel and 10mg of injectable methotrexate. A few years ago I tried carrying the dosing out as far as I could until I had a flare. I discovered 14 days was to much, but over the past 4 months I have been OK with dosing both medicines every 10 days. My question is Methotrexate specific, who is on lower doses of MTX? and what does anyone think about the benefit of instead of 10mg every 10 days, going to 5 mg every 5 days? Half life is less than a day, so I am unsure of the benefit with a really low dose of 5mg, but hope someone else is experimenting with this. I will be meeting with my Functional Rheumatologist in 2 weeks, hope she has an opinion, I have found no studies with this issue online