I have had RA now for at least 4 years now and have not found a medication that has helped except prednisone. I have tried MTX alone and with Enbrel. My first try at Humira caused an allergic reaction called angioedema. My doctor thought that it was such a rare reaction that it wasn't the Humira. So, we tried again and it happened quicker and worse. Orencia has been denied by my insurance co as they want me to go on Remicade next. Aren't Humira and Remicade too much alike? Will Orencia be any different in its makeup? I would really like to hear back if anyone has had experience with this.