... Mirapex while on opioids? I have a family member who is suffering with RLS ,but is also recovering from major surgery so he is on pain medication. His healthcare provider won't give him the medication he needs for the RLS because he says you can't mix RLS medication and opioid pain medication. We have three other family members who suffer with RLS and are on Mirapex and opioid pain medication and it has never been a issue.