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Why must I remain upright for >= 60 minutes after taking Boniva (ibandronate)?

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suzanne66 30 Apr 2018

Boniva (ibandronate) is a prescription medicine used to treat osteoporosis in women after menopause. Boniva helps increase bone mass which may prevent bone fractures.

Boniva can cause serious problems in the stomach or esophagus (for example, esophagitis, esophageal ulcers, esophageal erosions). This is more likely to occur when patients do not drink enough water with ibandronate, wait less than 60 minutes before lying down after taking ibandronate, or continue to take ibandronate after developing symptoms of esophageal irritation.

So the recommendations are that Boniva be swallowed whole with six to eight ounces of plain water while in an upright position, in order to be certain that the tablets enter the stomach. If the tablets stick in the esophagus they can irritate the esophagus. For the same reason, patients should not lie down for 60 minutes after taking ibandronate since tablets are more likely to stick in the esophagus when lying down.

Boniva should be taken at least 60 minutes before the first food or drink of the day (other than plain water) or before other oral medication, because of concern that that food or medication will interfere with the absorption of Boniva.

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