..a bottle it should work. I have suffered for so long, so many years, I finally get introduced to Relistor, only after my insurance informed me that Movantik was not on their formuIary list so the only med that worked every day is not covered, with Relistor first day 3 tabs, on a Friday, with in 4 hours I go, then went again later that day, I was so happy, I skipped a day because I went so much Fri, skipped Saturday, took 3 tabs Sunday, nothing at all happened took 3 tabs Mondays nothing? For a medication costing $2000.00 for a 1 month supply is crazy. Why is it not working?